{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:26:26Z","timestamp":1761560786336},"reference-count":24,"publisher":"American Society of Hematology","issue":"12","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,12,1]]},"abstract":"<jats:p>Iron accumulation in the liver in hereditary hemochromatosis (HH) has been shown to be highly variable. Some studies point to the importance of major histocompatibility complex (MHC) class I (MHC-I) and CD8+ cells as modifiers of iron overload. In this report, using mice knockout for H2Kb\u2212\/\u2212and H2Db\u2212\/\u2212 genes, it is demonstrated that lack of classical MHC-I molecules results in a spontaneous increase of nonheme iron content in the liver (mainly located in the hepatocytes) when compared to wild-type mice. In CD8\u2212\/\u2212and Rag2\u2212\/\u2212 mice, no spontaneous hepatic iron accumulation was observed. These results demonstrate for the first time that classical MHC-I molecules could be involved in the regulation of iron metabolism and contribute to the established genotype\/phenotype discrepancies seen in HH.<\/jats:p>","DOI":"10.1182\/blood-2002-05-1565","type":"journal-article","created":{"date-parts":[[2002,11,14]],"date-time":"2002-11-14T17:42:59Z","timestamp":1037295779000},"page":"4239-4241","update-policy":"http:\/\/dx.doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":22,"title":["Increased hepatic iron in mice lacking classical MHC class I molecules"],"prefix":"10.1182","volume":"100","author":[{"given":"Elsa M.","family":"Cardoso","sequence":"first","affiliation":[{"name":"From Molecular Immunology and Immunobiology, Institute for Molecular and Cell Biology; Instituto Superior de Cie\u0302ncias da Sau\u0301de-Norte; Molecular Immunology and Pathology, Instituto de Cie\u0302ncias Biome\u0301dicas Abel Salazar, Oporto, Portugal; Unite\u0301 d\u2032Immunite\u0301 Cellulaire Antivirale, Institut Pasteur, Paris, France."}]},{"given":"Maria G.","family":"Macedo","sequence":"additional","affiliation":[{"name":"From Molecular Immunology and Immunobiology, Institute for Molecular and Cell Biology; Instituto Superior de Cie\u0302ncias da Sau\u0301de-Norte; Molecular Immunology and Pathology, Instituto de Cie\u0302ncias Biome\u0301dicas Abel Salazar, Oporto, Portugal; Unite\u0301 d\u2032Immunite\u0301 Cellulaire Antivirale, Institut Pasteur, Paris, France."}]},{"given":"Pierre","family":"Rohrlich","sequence":"additional","affiliation":[{"name":"From Molecular Immunology and Immunobiology, Institute for Molecular and Cell Biology; Instituto Superior de Cie\u0302ncias da Sau\u0301de-Norte; Molecular Immunology and Pathology, Instituto de Cie\u0302ncias Biome\u0301dicas Abel Salazar, Oporto, Portugal; Unite\u0301 d\u2032Immunite\u0301 Cellulaire Antivirale, Institut Pasteur, Paris, France."}]},{"given":"Eduarda","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"From Molecular Immunology and Immunobiology, Institute for Molecular and Cell Biology; Instituto Superior de Cie\u0302ncias da Sau\u0301de-Norte; Molecular Immunology and Pathology, Instituto de Cie\u0302ncias Biome\u0301dicas Abel Salazar, Oporto, Portugal; Unite\u0301 d\u2032Immunite\u0301 Cellulaire Antivirale, Institut Pasteur, Paris, France."}]},{"given":"Manuel T.","family":"Silva","sequence":"additional","affiliation":[{"name":"From Molecular Immunology and Immunobiology, Institute for Molecular and Cell Biology; Instituto Superior de Cie\u0302ncias da Sau\u0301de-Norte; Molecular Immunology and Pathology, Instituto de Cie\u0302ncias Biome\u0301dicas Abel Salazar, Oporto, Portugal; Unite\u0301 d\u2032Immunite\u0301 Cellulaire Antivirale, Institut Pasteur, Paris, France."}]},{"given":"Franc\u0327ois A.","family":"Lemonnier","sequence":"additional","affiliation":[{"name":"From Molecular Immunology and Immunobiology, Institute for Molecular and Cell Biology; Instituto Superior de Cie\u0302ncias da Sau\u0301de-Norte; Molecular Immunology and Pathology, Instituto de Cie\u0302ncias Biome\u0301dicas Abel Salazar, Oporto, Portugal; Unite\u0301 d\u2032Immunite\u0301 Cellulaire Antivirale, Institut Pasteur, Paris, France."}]},{"given":"Maria","family":"de Sousa","sequence":"additional","affiliation":[{"name":"From Molecular Immunology and Immunobiology, Institute for Molecular and Cell Biology; Instituto Superior de Cie\u0302ncias da Sau\u0301de-Norte; Molecular Immunology and Pathology, Instituto de Cie\u0302ncias Biome\u0301dicas Abel Salazar, Oporto, Portugal; Unite\u0301 d\u2032Immunite\u0301 Cellulaire Antivirale, Institut Pasteur, Paris, France."}]}],"member":"234","reference":[{"key":"2019111610173084600_B1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng0896-399","article-title":"A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis.","volume":"13","author":"Feder","year":"1996","journal-title":"Nat Genet."},{"key":"2019111610173084600_B2","doi-asserted-by":"crossref","first-page":"8160","DOI":"10.1073\/pnas.161296298","article-title":"Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease.","volume":"98","author":"Fleming","year":"2001","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2019111610173084600_B3","first-page":"495","article-title":"Genetics of iron storage and hemochromatosis.","volume":"29","author":"Beutler","year":"2001","journal-title":"Drug Metab Dispos."},{"key":"2019111610173084600_B4","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1172\/JCI9635","article-title":"Genes that modify the hemochromatosis phenotype in mice.","volume":"105","author":"Levy","year":"2000","journal-title":"J Clin Invest."},{"key":"2019111610173084600_B5","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1017\/CBO9780511666476.039","article-title":"T lymphocyte expression and function in hemochromatosis.","volume-title":"wards CQ, eds. 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