{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T21:56:33Z","timestamp":1762898193046},"reference-count":41,"publisher":"American Society of Hematology","issue":"7","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mice lacking interleukin-7 (IL-7\u2013\/\u2013 mice) have no signs of autoimmune disease, contrary to other models of lymphopenia. We investigated whether the absence of disease was due to the fact that IL-7 is dispensable for the ontogeny, function, and homeostasis of regulatory CD4+ T cells. We show here that the establishment of the peripheral pool of Foxp3-expressing regulatory cells is IL-7 independent, and the premature involution of the thymus in IL-7\u2013\/\u2013 mice does not change the representation of the CD4+CD25+ T-cell compartment. In addition, CD4+CD25+ T cells expand in the absence of IL-7, without losing Foxp3 expression. The frequency of activated peripheral CD4+ T cells increases with age in both the CD25\u2013 and CD25+ compartments, with the CD4+CD25+ T cells displaying signs of constant activation. IL-7\u2013\/\u2013 CD4+CD25+ T cells control inflammatory bowel disease induced by IL-7\u2013\/\u2013 T cells even in hosts lacking IL-7. Depletion of the CD25+ T-cell subset after thymic involution results in a mild form of inflammatory bowel disease (IBD), which resolves concomitantly with the regeneration of this subset. This study shows for the first time that IL-7\u2013\/\u2013 mice have a robust regulatory Foxp3-expressing CD4+ T-cell compartment that controls T-cell\u2013mediated disease. It also highlights the potential of the regulatory Foxp3-expressing CD4+CD25\u2013 T-cell population to restore a functional CD4+CD25+ T-cell compartment through an IL-7\u2013independent pathway.<\/jats:p>","DOI":"10.1182\/blood-2006-04-017947","type":"journal-article","created":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T01:29:09Z","timestamp":1149816549000},"page":"2300-2306","update-policy":"http:\/\/dx.doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":35,"title":["Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7"],"prefix":"10.1182","volume":"108","author":[{"given":"Re\u0301gis Peffault","family":"de Latour","sequence":"first","affiliation":[{"name":"From the Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U 668, Unite\u0301 du De\u0301veloppement des Lymphocytes, and Unite\u0301 Cytokines et De\u0301veloppement lymphoi\u0308de, Institut Pasteur, Paris, France; Service d'Anatomo-Pathologie, Centre Jean-Perrin, Clermont-Ferrand, France; and Instituto de Ciencias Gulbenkian, Oeiras, Portugal."}]},{"given":"He\u0301le\u0300ne C.","family":"Dujardin","sequence":"additional","affiliation":[{"name":"From the Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U 668, Unite\u0301 du De\u0301veloppement des Lymphocytes, and Unite\u0301 Cytokines et De\u0301veloppement lymphoi\u0308de, Institut Pasteur, Paris, France; Service d'Anatomo-Pathologie, Centre Jean-Perrin, Clermont-Ferrand, France; and Instituto de Ciencias Gulbenkian, Oeiras, Portugal."}]},{"given":"Florence","family":"Mishellany","sequence":"additional","affiliation":[{"name":"From the Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U 668, Unite\u0301 du De\u0301veloppement des Lymphocytes, and Unite\u0301 Cytokines et De\u0301veloppement lymphoi\u0308de, Institut Pasteur, Paris, France; Service d'Anatomo-Pathologie, Centre Jean-Perrin, Clermont-Ferrand, France; and Instituto de Ciencias Gulbenkian, Oeiras, Portugal."}]},{"given":"Odile","family":"Burlen-Defranoux","sequence":"additional","affiliation":[{"name":"From the Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U 668, Unite\u0301 du De\u0301veloppement des Lymphocytes, and Unite\u0301 Cytokines et De\u0301veloppement lymphoi\u0308de, Institut Pasteur, Paris, France; Service d'Anatomo-Pathologie, Centre Jean-Perrin, Clermont-Ferrand, France; and Instituto de Ciencias Gulbenkian, Oeiras, Portugal."}]},{"given":"Julien","family":"Zuber","sequence":"additional","affiliation":[{"name":"From the Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U 668, Unite\u0301 du De\u0301veloppement des Lymphocytes, and Unite\u0301 Cytokines et De\u0301veloppement lymphoi\u0308de, Institut Pasteur, Paris, France; Service d'Anatomo-Pathologie, Centre Jean-Perrin, Clermont-Ferrand, France; and Instituto de Ciencias Gulbenkian, Oeiras, Portugal."}]},{"given":"Rute","family":"Marques","sequence":"additional","affiliation":[{"name":"From the Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U 668, Unite\u0301 du De\u0301veloppement des Lymphocytes, and Unite\u0301 Cytokines et De\u0301veloppement lymphoi\u0308de, Institut Pasteur, Paris, France; Service d'Anatomo-Pathologie, Centre Jean-Perrin, Clermont-Ferrand, France; and Instituto de Ciencias Gulbenkian, Oeiras, Portugal."}]},{"given":"James","family":"Di Santo","sequence":"additional","affiliation":[{"name":"From the Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U 668, Unite\u0301 du De\u0301veloppement des Lymphocytes, and Unite\u0301 Cytokines et De\u0301veloppement lymphoi\u0308de, Institut Pasteur, Paris, France; Service d'Anatomo-Pathologie, Centre Jean-Perrin, Clermont-Ferrand, France; and Instituto de Ciencias Gulbenkian, Oeiras, Portugal."}]},{"given":"Ana","family":"Cumano","sequence":"additional","affiliation":[{"name":"From the Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U 668, Unite\u0301 du De\u0301veloppement des Lymphocytes, and Unite\u0301 Cytokines et De\u0301veloppement lymphoi\u0308de, Institut Pasteur, Paris, France; Service d'Anatomo-Pathologie, Centre Jean-Perrin, Clermont-Ferrand, France; and Instituto de Ciencias Gulbenkian, Oeiras, Portugal."}]},{"given":"Paulo","family":"Vieira","sequence":"additional","affiliation":[{"name":"From the Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U 668, Unite\u0301 du De\u0301veloppement des Lymphocytes, and Unite\u0301 Cytokines et De\u0301veloppement lymphoi\u0308de, Institut Pasteur, Paris, France; Service d'Anatomo-Pathologie, Centre Jean-Perrin, Clermont-Ferrand, France; and Instituto de Ciencias Gulbenkian, Oeiras, Portugal."}]},{"given":"Antonio","family":"Bandeira","sequence":"additional","affiliation":[{"name":"From the Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U 668, Unite\u0301 du De\u0301veloppement des Lymphocytes, and Unite\u0301 Cytokines et De\u0301veloppement lymphoi\u0308de, Institut Pasteur, Paris, France; Service d'Anatomo-Pathologie, Centre Jean-Perrin, Clermont-Ferrand, France; and Instituto de Ciencias Gulbenkian, Oeiras, Portugal."}]}],"member":"234","reference":[{"key":"2019111711271636900_REF1","doi-asserted-by":"crossref","unstructured":"Freitas AA, Rocha B. 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