{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:23:28Z","timestamp":1778509408000,"version":"3.51.4"},"reference-count":39,"publisher":"American Society of Hematology","issue":"13","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The CD31+ subset of human naive CD4+ T cells is thought to contain the population of cells that have recently emigrated from the thymus, while their CD31\u2212 counterparts have been proposed to originate from CD31+ cells after homeostatic cell division. Naive T-cell maintenance is known to involve homeostatic cytokines such as interleukin-7 (IL-7). It remains to be investigated what role this cytokine has in the homeostasis of naive CD4+ T-cell subsets defined by CD31 expression. We provide evidence that IL-7 exerts a preferential proliferative effect on CD31+ naive CD4+ T cells from adult peripheral blood compared with the CD31\u2212 subset. IL-7\u2013driven proliferation did not result in loss of CD31 expression, suggesting that CD31+ naive CD4+ T cells can undergo cytokine-driven homeostatic proliferation while preserving CD31. Furthermore, IL-7 sustained or increased CD31 expression even in nonproliferating cells. Both proliferation and CD31 maintenance were dependent on the activation of phosphoinositide 3-kinase (PI3K) signaling. Taken together, our data suggest that during adulthood CD31+ naive CD4+ T cells are maintained by IL-7 and that IL-7\u2013based therapies may exert a preferential effect on this population.<\/jats:p>","DOI":"10.1182\/blood-2008-07-166223","type":"journal-article","created":{"date-parts":[[2008,11,14]],"date-time":"2008-11-14T02:36:12Z","timestamp":1226630172000},"page":"2999-3007","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":67,"title":["IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner"],"prefix":"10.1182","volume":"113","author":[{"given":"Rita I.","family":"Azevedo","sequence":"first","affiliation":[{"name":"Unidade de Imunologia Cl\u00ednica,"}]},{"given":"Maria Vieira D.","family":"Soares","sequence":"additional","affiliation":[{"name":"Unidade de Imunologia Cl\u00ednica,"}]},{"given":"Jo\u00e3o T.","family":"Barata","sequence":"additional","affiliation":[{"name":"Unidade de Biologia do Cancro, and"}]},{"given":"Rita","family":"Tendeiro","sequence":"additional","affiliation":[{"name":"Unidade de Imunologia Cl\u00ednica,"}]},{"given":"Ana","family":"Serra-Caetano","sequence":"additional","affiliation":[{"name":"Unidade de Citometria de Fluxo, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"}]},{"given":"Rui M. 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