{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:20:30Z","timestamp":1767860430193,"version":"3.49.0"},"reference-count":26,"publisher":"American Society of Hematology","issue":"12","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,3,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>On the path to successful immunotherapy of hematopoietic tumors, \u03b3\u03b4 T cells offer great promise because of their human leukocyte antigen (HLA)\u2013unrestricted targeting of a wide variety of leukemias\/lymphomas. However, the molecular mechanisms underlying lymphoma recognition by \u03b3\u03b4 T cells remain unclear. Here we show that the expression levels of UL16-binding protein 1 (ULBP1) determine lymphoma susceptibility to \u03b3\u03b4 T cell\u2013mediated cytolysis. Consistent with this, blockade of NKG2D, the receptor for ULBP1 expressed on all V\u03b39+ T cells, significantly inhibits lymphoma cell killing. Specific loss-of-function studies demonstrate that the role of ULBP1 is nonredundant, highlighting a thus far unique physiologic relevance for tumor recognition by \u03b3\u03b4 T cells. Importantly, we observed a very wide spectrum of ULBP1 expression levels in primary biopsies obtained from lymphoma and leukemia patients. We suggest this will impact on the responsiveness to \u03b3\u03b4 T cell\u2013based immunotherapy, and therefore propose ULBP1 to be used as a leukemia\/lymphoma biomarker in upcoming clinical trials.<\/jats:p>","DOI":"10.1182\/blood-2009-08-237123","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T02:52:47Z","timestamp":1264474367000},"page":"2407-2411","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":107,"title":["The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia\/lymphoma susceptibility to \u03b3\u03b4 T-cell cytotoxicity"],"prefix":"10.1182","volume":"115","author":[{"given":"Telma","family":"Lan\u00e7a","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa;"}]},{"given":"Daniel V.","family":"Correia","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa;"},{"name":"Instituto Gulbenkian de Ci\u00eancia, Oeiras;"}]},{"given":"Catarina F.","family":"Moita","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa;"}]},{"given":"Helena","family":"Raquel","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa;"}]},{"given":"Ana","family":"Neves-Costa","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa;"}]},{"given":"Cristina","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Hospital de Santa Maria Centro Hospitalar Lisboa Norte, Lisboa;"}]},{"given":"Jos\u00e9 S.","family":"Ramalho","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, Lisboa; and"}]},{"given":"Jo\u00e3o T.","family":"Barata","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa;"}]},{"given":"Lu\u00eds F.","family":"Moita","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa;"}]},{"given":"Anita Q.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa;"},{"name":"Instituto Gulbenkian de Ci\u00eancia, Oeiras;"},{"name":"Escola Superior de Tecnologia da Sa\u00fade de Lisboa, Lisboa, Portugal"}]},{"given":"Bruno","family":"Silva-Santos","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa;"},{"name":"Instituto Gulbenkian de Ci\u00eancia, 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