{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:07:21Z","timestamp":1772165241728,"version":"3.50.1"},"reference-count":43,"publisher":"American Society of Hematology","issue":"24","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,12,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The C-type lectin receptor Dectin-1 plays a pivotal role in antifungal immunity. In this study, the recently characterized human DECTIN1 Y238X early stop codon polymorphism leading to diminished Dectin-1 receptor activity was studied in relation to invasive aspergillosis susceptibility and severity in patients receiving hematopoietic stem cell transplantation. We found that the presence of the DECTIN1 Y238X polymorphism in either donors or recipients of hematopoietic stem cell transplantation increased susceptibility to aspergillosis, with the risk being highest when the polymorphism was present simultaneously in both donors and recipients (adjusted hazard ratio = 3.9; P = .005). Functionally, the Y238X polymorphism impaired the production of interferon-\u03b3 and interleukin-10 (IL-10), in addition to IL-1\u03b2, IL-6, and IL-17A, by human peripheral mononuclear cells and Dectin-1 on human epithelial cells contributed to fungal recognition. Mechanistically, studies on preclinical models of infection in intact or bone marrow-transplanted Dectin-1 knockout mice revealed that protection from infection requires a distinct, yet complementary, role of both donor and recipient Dectin-1. This study discloses Dectin-1 deficiency as a novel susceptibility factor for aspergillosis in high-risk patients and identifies a previously unsuspected role for Dectin-1 in antifungal immunity that is the ability to control both resistance and tolerance to the fungus contingent on hematopoietic\/nonhematopoietic compartmentalization.<\/jats:p>","DOI":"10.1182\/blood-2010-04-279307","type":"journal-article","created":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T22:26:10Z","timestamp":1283293570000},"page":"5394-5402","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":253,"title":["Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity"],"prefix":"10.1182","volume":"116","author":[{"given":"Cristina","family":"Cunha","sequence":"first","affiliation":[{"name":"Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy;"}]},{"given":"Mauro","family":"Di Ianni","sequence":"additional","affiliation":[{"name":"Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy;"}]},{"given":"Silvia","family":"Bozza","sequence":"additional","affiliation":[{"name":"Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy;"}]},{"given":"Gloria","family":"Giovannini","sequence":"additional","affiliation":[{"name":"Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy;"}]},{"given":"Silvia","family":"Zagarella","sequence":"additional","affiliation":[{"name":"Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy;"}]},{"given":"Teresa","family":"Zelante","sequence":"additional","affiliation":[{"name":"Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy;"}]},{"given":"Carmen","family":"D'Angelo","sequence":"additional","affiliation":[{"name":"Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy;"}]},{"given":"Antonio","family":"Pierini","sequence":"additional","affiliation":[{"name":"Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy;"}]},{"given":"Lucia","family":"Pitzurra","sequence":"additional","affiliation":[{"name":"Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy;"}]},{"given":"Franca","family":"Falzetti","sequence":"additional","affiliation":[{"name":"Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy;"}]},{"given":"Alessandra","family":"Carotti","sequence":"additional","affiliation":[{"name":"Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy;"}]},{"given":"Katia","family":"Perruccio","sequence":"additional","affiliation":[{"name":"Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy;"}]},{"given":"Jean-Paul","family":"Latg\u00e9","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Aspergillus, Institut Pasteur, Paris, France; and"}]},{"given":"Fernando","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal"}]},{"given":"Andrea","family":"Velardi","sequence":"additional","affiliation":[{"name":"Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy;"}]},{"given":"Franco","family":"Aversa","sequence":"additional","affiliation":[{"name":"Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy;"}]},{"given":"Luigina","family":"Romani","sequence":"additional","affiliation":[{"name":"Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy;"}]},{"given":"Agostinho","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Microbiology Section, Department of 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