{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:33:12Z","timestamp":1762101192085},"reference-count":40,"publisher":"American Society of Hematology","issue":"3","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The brain and dendritic cell (BAD)\u2013associated lysosome-associated membrane protein (LAMP)\u2013like molecule (BAD-LAMP, c20orf103, UNC-46) is a newly identified member of the family of LAMPs. BAD-LAMP expression in the mouse is confined to neurons. We demonstrate here that in humans, BAD-LAMP can specifically be found in the type I IFN-producing plasmacytoid dendritic cells (pDCs). Human BAD-LAMP is localized in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) of freshly isolated CD123+ pDCs and is rapidly lost upon activation by unmethylated cytosine-phosphate-guanine (CpG) oligonucleotides. The restricted pattern of BAD-LAMP expression allows for the rapid identification of normal and leukemic human pDCs in tissues and blood.<\/jats:p>","DOI":"10.1182\/blood-2010-11-319699","type":"journal-article","created":{"date-parts":[[2011,6,4]],"date-time":"2011-06-04T00:48:21Z","timestamp":1307148501000},"page":"609-617","update-policy":"http:\/\/dx.doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":30,"title":["BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid dendritic cells"],"prefix":"10.1182","volume":"118","author":[{"given":"Axel","family":"Defays","sequence":"first","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France;"},{"name":"Inserm, Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Marseille, France;"}]},{"given":"Alexandre","family":"David","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France;"},{"name":"Inserm, Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Marseille, France;"}]},{"given":"Aude","family":"de Gassart","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France;"},{"name":"Inserm, Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Marseille, France;"}]},{"given":"Francesca","family":"De Angelis Rigotti","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France;"},{"name":"Inserm, Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Marseille, France;"}]},{"given":"Till","family":"Wenger","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Universit\u00e9 de la 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