{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:45:31Z","timestamp":1777045531435,"version":"3.51.4"},"reference-count":25,"publisher":"American Society of Hematology","issue":"17","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,4,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Natural cytotoxicity receptors (NCRs) were originally identified as specific natural killer cell activating receptors that, on binding to their endogenous ligands, trigger the killing of tumor cell targets. We recently described the differentiation of a novel subset of NCR+ V\u03b41 T cells characterized by a remarkably high cytolytic potential against cancer cells. Here we demonstrate that the engagement of NKp30, one of the NCRs expressed de novo on V\u03b41 T cells after stimulation, triggers the production of high levels of CCL3\/MIP-1\u03b1, CCL4\/ MIP-1\u03b2, and CCL5\/RANTES but not of CXCL12\/SDF-1. In turn, this NKp30-induced secretion of cc-chemokines is able to significantly suppress the replication of a CCR5 tropic strain of HIV-1 in CD4+\/CCR5+ infected PM1 cell lines. This experimental evidence disclosing an unanticipated antiviral function of NCR+ V\u03b41 T cells opens new avenues for understanding the pathogenic role and for manipulating the function of \u03b3\u03b4 T cells in HIV-1 infection.<\/jats:p>","DOI":"10.1182\/blood-2011-11-390153","type":"journal-article","created":{"date-parts":[[2012,3,9]],"date-time":"2012-03-09T05:55:44Z","timestamp":1331272544000},"page":"4013-4016","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":91,"title":["Engagement of NKp30 on V\u03b41 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication"],"prefix":"10.1182","volume":"119","author":[{"given":"Kelly","family":"Hudspeth","sequence":"first","affiliation":[{"name":"Laboratory of Clinical and Experimental Immunology, Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Clinico Humanitas, Rozzano, Milan, Italy;"}]},{"given":"Manuela","family":"Fogli","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy;"}]},{"given":"Daniel V.","family":"Correia","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal; and"}]},{"given":"Joanna","family":"Mikulak","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Immunology, Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Clinico Humanitas, Rozzano, Milan, Italy;"}]},{"given":"Alessandra","family":"Roberto","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Immunology, Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Clinico Humanitas, Rozzano, Milan, Italy;"}]},{"given":"Silvia","family":"Della Bella","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Immunology, Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Clinico Humanitas, Rozzano, Milan, Italy;"},{"name":"Section of Microbiology, Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy;"},{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal; and"},{"name":"Department of Translational Medicine, University of Milan, Milan, Italy"}]},{"given":"Bruno","family":"Silva-Santos","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal; and"}]},{"given":"Domenico","family":"Mavilio","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Immunology, Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Clinico Humanitas, Rozzano, Milan, 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