{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:41:20Z","timestamp":1766180480489},"reference-count":50,"publisher":"American Society of Hematology","issue":"10","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,9,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Invariant natural killer T (iNKT) cells can experimentally dissociate GVL from graft-versus-host-disease (GVHD). Their role in human conventional allogeneic hematopoietic stem cell transplantation (HSCT) is unknown. Here, we analyzed the post-HSCT recovery of iNKT cells in 71 adult allografted patients. Results were compared with conventional T- and NK-cell recovery and correlated to the occurrence of GVHD, relapse, and survival. We observed that posttransplantation iNKT cells, likely of donor origin, recovered independently of T and NK cells in the first 90 days after HSCT and reached greater levels in recipient younger than 45 years (P = .003) and after a reduced-intensity conditioning regimen (P = .03). Low posttransplantation iNKT\/T ratios (ie, &lt; 10\u22123) were an independent factor associated with the occurrence of acute GVHD (aGVHD; P = .001). Inversely, reaching iNKT\/T ratios &gt; 10\u22123 before day 90 was associated with reduced nonrelapse mortality (P = .009) without increased risk of relapse and appeared as an independent predictive factor of an improved overall survival (P = .028). Furthermore, an iNKT\/T ratio on day 15 &gt; 0.58 \u00d7 10\u22123 was associated with a 94% risk reduction of aGVHD. These findings provide a proof of concept that early postallogeneic HSCT iNKT cell recovery can predict the occurrence of aGVHD and an improved overall survival.<\/jats:p>","DOI":"10.1182\/blood-2012-01-404673","type":"journal-article","created":{"date-parts":[[2012,6,23]],"date-time":"2012-06-23T04:21:08Z","timestamp":1340425268000},"page":"2144-2154","update-policy":"http:\/\/dx.doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":103,"title":["Early posttransplantation donor-derived invariant natural killer T-cell recovery predicts the occurrence of acute graft-versus-host disease and overall survival"],"prefix":"10.1182","volume":"120","author":[{"given":"Marie-Th\u00e9r\u00e8se","family":"Rubio","sequence":"first","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Department, Saint Antoine Hospital, Assistance Publique des H\u00f4pitaux de Paris (AP-HP) 184, Paris, France;"},{"name":"Unit\u00e9 Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes, Paris V, H\u00f4pital Necker, Paris, France;"}]},{"given":"Lucia","family":"Moreira-Teixeira","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes, Paris V, H\u00f4pital Necker, Paris, France;"}]},{"given":"Emmanuel","family":"Bachy","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Lyon Sud, Pierre-B\u00e9nite, France;"}]},{"given":"Marie","family":"Bouilli\u00e9","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes, Paris V, H\u00f4pital Necker, Paris, France;"}]},{"given":"Pierre","family":"Milpied","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes, Paris V, H\u00f4pital Necker, Paris, France;"}]},{"given":"Tereza","family":"Coman","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes, Paris V, H\u00f4pital Necker, Paris, France;"}]},{"given":"Felipe","family":"Suarez","sequence":"additional","affiliation":[{"name":"Adult Hematology Department, Necker Hospital, AP-HP 149, Paris, France;"}]},{"given":"Ambroise","family":"Marcais","sequence":"additional","affiliation":[{"name":"Adult Hematology Department, Necker Hospital, AP-HP 149, Paris, France;"}]},{"given":"David","family":"Sibon","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes, Paris V, H\u00f4pital Necker, Paris, France;"},{"name":"Adult Hematology Department, Necker Hospital, AP-HP 149, Paris, France;"}]},{"given":"Agn\u00e8s","family":"Buzyn","sequence":"additional","affiliation":[{"name":"Adult Hematology Department, Necker Hospital, AP-HP 149, Paris, France;"}]},{"given":"Sophie","family":"Caillat-Zucman","sequence":"additional","affiliation":[{"name":"Immunology Laboratory, Necker Hospital 149, Paris, France;"}]},{"given":"Marina","family":"Cavazzana-Calvo","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Bioth\u00e9rapie, H\u00f4pital Necker Enfants Malades, AP-HP, Paris, France; and"},{"name":"Imagine Institut Hospital Universitaire Necker, Paris, France"}]},{"given":"Bruno","family":"Varet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes, Paris V, H\u00f4pital Necker, Paris, France;"},{"name":"Adult Hematology Department, Necker Hospital, AP-HP 149, Paris, France;"}]},{"given":"Michel","family":"Dy","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes, Paris V, H\u00f4pital Necker, Paris, France;"}]},{"given":"Olivier","family":"Hermine","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes, Paris V, H\u00f4pital Necker, Paris, France;"},{"name":"Adult Hematology Department, Necker Hospital, AP-HP 149, Paris, France;"},{"name":"Imagine Institut Hospital Universitaire Necker, Paris, France"}]},{"given":"Maria","family":"Leite-de-Moraes","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Facult\u00e9 de M\u00e9decine Ren\u00e9 Descartes, Paris V, H\u00f4pital Necker, Paris, 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