{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:47:50Z","timestamp":1769276870089,"version":"3.49.0"},"reference-count":46,"publisher":"American Society of Hematology","issue":"23","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,11,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Antibody-forming cells (AFCs) expressing the chemokine receptor CXCR3 are recruited to sites of inflammation where they help clear pathogens but may participate in autoimmune diseases. Here we identify a mechanism that induces CXCR3 expression by AFC and germinal center (GC) B cells. This happens when CD8 T cells are recruited into CD4 T cell\u2013dependent B-cell responses. Ovalbumin-specific CD4 T cells (OTII) were transferred alone or with ovalbumin-specific CD8 T cells (OTI) and the response to subcutaneous alum-precipitated ovalbumin was followed in the draining lymph nodes. OTII cells alone induce T helper 2-associated class switching to IgG1, but few AFC or GC B cells express CXCR3. By contrast, OTI-derived IFN-\u03b3 induces most responding GC B cells and AFCs to express high levels of CXCR3, and diverse switching to IgG2a, IgG2b, with some IgG1. Up-regulation of CXCR3 by GC B cells and AFCs and their migration toward its ligand CXCL10 are shown to depend on B cells' intrinsic T-bet, a transcription factor downstream of the IFN-\u03b3R signaling. This model clarifies how precursors of long-lived AFCs and memory B cells acquire CXCR3 that causes their migration to inflammatory foci.<\/jats:p>","DOI":"10.1182\/blood-2012-03-417733","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T21:30:48Z","timestamp":1350077448000},"page":"4552-4559","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":37,"title":["CD8 T cells induce T-bet\u2013dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines"],"prefix":"10.1182","volume":"120","author":[{"given":"Karine","family":"Serre","sequence":"first","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom;"},{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal;"}]},{"given":"Adam F.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom;"}]},{"given":"Ruth E.","family":"Coughlan","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom;"}]},{"given":"Andreia C.","family":"Lino","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal; and"}]},{"given":"Antal","family":"Rot","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom;"}]},{"given":"Elin","family":"Hub","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom;"}]},{"given":"Katrin","family":"Moser","sequence":"additional","affiliation":[{"name":"Institute for Systemic Inflammation Research, University of L\u00fcbeck, L\u00fcbeck, Germany"}]},{"given":"Rudolf","family":"Manz","sequence":"additional","affiliation":[{"name":"Institute for Systemic Inflammation Research, University of L\u00fcbeck, L\u00fcbeck, Germany"}]},{"given":"Alastair","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom;"}]},{"given":"Roger","family":"Bird","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom;"}]},{"given":"Kai-Michael","family":"Toellner","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom;"}]},{"given":"Jocelyne","family":"Demengeot","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal; and"}]},{"given":"Ian C. 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