{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:57:01Z","timestamp":1777964221639,"version":"3.51.4"},"reference-count":63,"publisher":"American Society of Hematology","issue":"1","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aging is associated with impaired hematopoietic and immune function caused in part by decreased fitness in the hematopoietic stem cell (HSC) population and an increased myeloid differentiation bias. The reasons for this aging-associated HSC impairment are incompletely understood. Here we demonstrate that older specific pathogen free (SPF) wild-type (WT) mice in contrast to young SPF mice produce more interleukin-1a and interleukin-1b (IL-1a\/b) in steady-state bone marrow (BM), with most of the IL-1a\/b being derived from myeloid BM cells. Furthermore, blood from steady-state older SPF WT mice contains higher levels of microbe-associated molecular patterns, specifically TLR4 and TLR8 ligands. In addition, BM myeloid cells from older mice produce more IL-1b in\u00a0vitro, and older mice show higher and more durable IL-1a\/b responses upon stimulation with lipopolysaccharide in\u00a0vivo. To test whether HSC aging is driven by IL-1a\/b, we evaluated HSCs from IL-1 receptor 1 (IL-1R1) knockout (KO) mice. Indeed, older HSCs from IL-1R1KO mice show significantly mitigated aging-associated inflammatory signatures. Moreover, HSCs from older IL-1R1KO and from germ-free mice maintain unbiased lymphomyeloid hematopoietic differentiation upon transplantation, thus resembling this functionality of young HSCs. Importantly, in\u00a0vivo antibiotic suppression of microbiota or pharmacologic blockade of IL-1 signaling in older WT mice was similarly sufficient to reverse myeloid-biased output of their HSC populations. Collectively, our data define the microbiome\/IL-1\/IL-1R1 axis as a key, self-sustaining and also therapeutically partially reversible driver of HSC inflammaging.<\/jats:p>","DOI":"10.1182\/blood.2021011570","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T13:59:40Z","timestamp":1631714380000},"page":"44-58","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":146,"title":["IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice"],"prefix":"10.1182","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0342-3127","authenticated-orcid":false,"given":"Larisa V.","family":"Kovtonyuk","sequence":"first","affiliation":[{"name":"Department of Medical Oncology and Hematology, University Hospital Zurich, Comprehensive Cancer Center Zurich, University of Zurich, Zurich, Switzerland;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4096-4448","authenticated-orcid":false,"given":"Francisco","family":"Caiado","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, University Hospital Zurich, Comprehensive Cancer Center Zurich, University of Zurich, Zurich, Switzerland;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-9446","authenticated-orcid":false,"given":"Santiago","family":"Garcia-Martin","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Structural Biology Department, Spanish National Cancer Research Centre, Madrid, Spain;"}]},{"given":"Eva-Maria","family":"Manz","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, University Hospital Zurich, Comprehensive Cancer Center Zurich, University of Zurich, Zurich, Switzerland;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6488-2805","authenticated-orcid":false,"given":"Patrick","family":"Helbling","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, University Hospital Zurich, Comprehensive Cancer Center Zurich, University of Zurich, Zurich, Switzerland;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5276-5430","authenticated-orcid":false,"given":"Hitoshi","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, University Hospital Zurich, Comprehensive Cancer Center Zurich, University of Zurich, Zurich, Switzerland;"},{"name":"Laboratory of Stem Cell Stress, International Research Center for Medical Sciences and Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, Japan; and"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9937-0957","authenticated-orcid":false,"given":"Steffen","family":"Boettcher","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, University Hospital Zurich, Comprehensive Cancer Center Zurich, University of Zurich, Zurich, Switzerland;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2373-769X","authenticated-orcid":false,"given":"Fatima","family":"Al-Shahrour","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Structural Biology Department, Spanish National Cancer Research Centre, Madrid, Spain;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0415-259X","authenticated-orcid":false,"given":"Cesar","family":"Nombela-Arrieta","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, University Hospital Zurich, Comprehensive Cancer Center Zurich, University of Zurich, Zurich, Switzerland;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2473-1145","authenticated-orcid":false,"given":"Emma","family":"Slack","sequence":"additional","affiliation":[{"name":"Laboratory for Food Immunology, Department of Health Sciences and Technology, Institute of Food, Nutrition and Health, ETH Z\u00fcrich, Zurich, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-7931","authenticated-orcid":false,"given":"Markus G.","family":"Manz","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, University Hospital Zurich, Comprehensive Cancer Center Zurich, University of Zurich, Zurich, Switzerland;"}]}],"member":"234","reference":[{"key":"2022010616204300800_B1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3389\/fimmu.2016.00502","article-title":"Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment","volume":"7","author":"Kovtonyuk","year":"2016","journal-title":"Front 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