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Investigations are only needed when in doubt about the diagnosis.<\/jats:p>\n                  <jats:p>\n                    Based on the limited evidence available, inhaled short-acting \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    -agonists by metered-dose inhaler\/spacer combination are recommended for symptomatic relief. Educating parents regarding causative factors and treatment is useful. Exposure to tobacco smoke should be avoided; allergen avoidance may be considered when sensitisation has been established. Maintenance treatment with inhaled corticosteroids is recommended for multiple-trigger wheeze; benefits are often small. Montelukast is recommended for the treatment of episodic (viral) wheeze and can be started when symptoms of a viral cold develop.\n                  <\/jats:p>\n                  <jats:p>Given the large overlap in phenotypes, and the fact that patients can move from one phenotype to another, inhaled corticosteroids and montelukast may be considered on a trial basis in almost any preschool child with recurrent wheeze, but should be discontinued if there is no clear clinical benefit.<\/jats:p>\n                  <jats:p>Large well-designed randomised controlled trials with clear descriptions of patients are needed to improve the present recommendations on the treatment of these common syndromes.<\/jats:p>","DOI":"10.1183\/09031936.00002108","type":"journal-article","created":{"date-parts":[[2008,9,30]],"date-time":"2008-09-30T13:38:55Z","timestamp":1222781935000},"page":"1096-1110","source":"Crossref","is-referenced-by-count":683,"title":["Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach"],"prefix":"10.1183","volume":"32","author":[{"given":"P. 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