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On multivariate analysis, age, St George\u2019s Respiratory Questionnaire activity score,<jats:italic>Pseudomonas aeruginosa<\/jats:italic>infection, total lung capacity (TLC), residual volume\/TLC and the transfer factor coefficient were all independently associated with mortality.<\/jats:p><jats:p>In patients with moderate to severe bronchiectasis, mortality is associated with a degree of restrictive and obstructive disease, poor gas transfer and chronic pseudomonas infection. These features should guide future research into disease progression, and identify those patients needing intensive treatment.<\/jats:p>","DOI":"10.1183\/09031936.00003709","type":"journal-article","created":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T00:44:59Z","timestamp":1239237899000},"page":"843-849","source":"Crossref","is-referenced-by-count":345,"title":["Mortality in bronchiectasis: a long-term study assessing the factors influencing survival"],"prefix":"10.1183","volume":"34","author":[{"given":"M. R.","family":"Loebinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. U.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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