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The primary outcome parameter was forced expiratory flow at 75% of forced vital capacity (FEF<jats:sub>75%<\/jats:sub>).<\/jats:p><jats:p>FEF<jats:sub>75%<\/jats:sub>increased significantly by 0.7<jats:sc>sd<\/jats:sc>(5.2% predicted) in the large airways group and 1.2<jats:sc>sd<\/jats:sc>(8.8% pred) in the small airways group. Intention-to-treat analysis did not show a significant difference in treatment effect between groups. Per-protocol analysis, excluding patients not completing the trial or with adherence &lt;70%, showed a trend (p=0.06) in FEF<jats:sub>75%<\/jats:sub>Z-score and a significant difference (p=0.04) between groups in absolute FEF<jats:sub>75%<\/jats:sub>(L\u00b7s<jats:sup>\u22121<\/jats:sup>) favouring small airway deposition.<\/jats:p><jats:p>Improved delivery of dornase alfa using a smart nebuliser that aids patients in correct inhalation technique resulted in significant improvement of FEF<jats:sub>75%<\/jats:sub>in children with stable cystic fibrosis. 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