{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:26:53Z","timestamp":1791210413024,"version":"4.1.0"},"reference-count":25,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,3,12]]},"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p>Common bile duct ligation (CBDL) induces biliary cirrhosis and pulmonary vasodilatation. We tested whether CBDL ameliorates monocrotaline (MCT)-induced pulmonary hypertension (PH) in rats.<\/jats:p><jats:p>Five groups of rats were studied: controls; rats dosed with MCT (60\u2005mg\u00b7kg<jats:sup>\u22121<\/jats:sup>subcutaneously); CBDL; rats dosed with MCT followed by CBDL on day\u20057; and rats dosed with MCT followed by CBDL (day\u20057) and<jats:sc>L<\/jats:sc>-NAME therapy between days 24 and 28. 28-day survival was 26% in the MCT group and 72% in the MCT+CBDL group. Pulmonary vascular resistance measured on days\u200521 and 28 increased in the MCT and MCT+CBDL+<jats:sc>L<\/jats:sc>-NAME groups, but returned to normal in the MCT+CBDL group on day\u200528. Pulmonary artery (PA) medial hypertrophy persisted in MCT+CBDL rats. PA inflammation increased in MCT+CBDL rats, with accumulation of both intra- and perivascular macrophages. Exhaled nitric oxide (NO) levels decreased in the MCT group and increased in the MCT+CBDL group, which showed upregulation of inducible NO synthase and normal endothelial NO synthase. Blood endothelin (ET)-1 increased in CBDL, MCT, and MCT+CBDL rats. Levels of ET<jats:sub>B<\/jats:sub>receptors increased and ET<jats:sub>A<\/jats:sub>receptors decreased in the MCT+CBDL group, whereas the opposite changes occurred in the MCT group.<\/jats:p><jats:p>Biliary cirrhosis induces pulmonary vasodilation that ameliorates MCT-induced PH and improves survival. Upregulation of inducible NO synthase and ET<jats:sub>B<\/jats:sub>receptor and downregulation of ET<jats:sub>A<\/jats:sub>receptor may be involved.<\/jats:p>","DOI":"10.1183\/09031936.00006508","type":"journal-article","created":{"date-parts":[[2009,3,27]],"date-time":"2009-03-27T00:45:36Z","timestamp":1238114736000},"page":"731-739","source":"Crossref","is-referenced-by-count":6,"title":["Cirrhosis ameliorates monocrotaline-induced pulmonary hypertension in rats"],"prefix":"10.1183","volume":"34","author":[{"given":"J.","family":"Le 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