{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T16:09:09Z","timestamp":1769530149482,"version":"3.49.0"},"reference-count":47,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,4,26]]},"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>Animal models suggest that vitamin A deficiency affects lung development adversely and promotes airway hyperresponsiveness, and may predispose to an increased risk of asthma. We examined the long-term effects of vitamin A supplementation early in life on later asthma risk.<\/jats:p><jats:p>In 2006\u20132008, we revisited participants from two cohorts in rural Nepal who were enrolled in randomised trials of vitamin A supplementation. The first cohort received vitamin A or placebo for &lt;16 months during their pre-school years (1989\u20131991). The second cohort was born to mothers who received vitamin A, \u03b2-carotene or placebo before, during and after pregnancy (1994\u20131997). At follow-up, we asked about asthma symptoms and performed spirometry.<\/jats:p><jats:p>Out of 6,421 subjects eligible to participate, 5,430 (85%) responded to our respiratory survey. Wheezing prevalence during the previous year was 4.8% in participants aged 9\u201313 yrs and 6.6% in participants aged 14\u201323 yrs. We found no differences between the vitamin A supplemented and placebo groups from either trial in the prevalence of lifetime or current asthma and wheeze or in spirometric indices of obstruction (p\u22650.12 for all comparisons).<\/jats:p><jats:p>Vitamin A supplementation early in life was not associated with a decreased risk of asthma in an area with chronic vitamin A deficiency.<\/jats:p>","DOI":"10.1183\/09031936.00006911","type":"journal-article","created":{"date-parts":[[2011,6,24]],"date-time":"2011-06-24T00:44:40Z","timestamp":1308876280000},"page":"1310-1319","source":"Crossref","is-referenced-by-count":47,"title":["Supplementation with vitamin A early in life and subsequent risk of asthma"],"prefix":"10.1183","volume":"38","author":[{"given":"W.","family":"Checkley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"K.P.","family":"West","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.A.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.C.","family":"LeClerq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Khatry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Christian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Tielsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2011,6,23]]},"reference":[{"key":"2024102020421037000_38.6.1310.1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.1_suppl.4S"},{"key":"2024102020421037000_38.6.1310.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00526.x"},{"key":"2024102020421037000_38.6.1310.3","first-page":"548","article-title":"The public health implications of asthma","volume":"83","author":"Bousquet","year":"2005","journal-title":"Bull World Health Organ"},{"key":"2024102020421037000_38.6.1310.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)01151-3"},{"key":"2024102020421037000_38.6.1310.5","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.1.8542133"},{"key":"2024102020421037000_38.6.1310.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102013440507"},{"key":"2024102020421037000_38.6.1310.7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/oxfordjournals.aje.a115644","article-title":"Dietary factors and their relation to respiratory symptoms. 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