{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:19:51Z","timestamp":1787019591533,"version":"build-2736575974"},"reference-count":27,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2008,5,2]]},"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>There is increasing evidence that inflammation plays an important role in the development of cardiovascular complications in patients with obstructive sleep apnoea (OSA).<\/jats:p>\n                  <jats:p>No previous works have studied levels of soluble tumour necrosis factor-\u03b1 receptor (sTNFR)-1 in patients with OSA. The aims of the present study were to examine serum levels of sTNFR-1 and the effect of nasal continuous positive airway pressure (CPAP) in patients with OSA.<\/jats:p>\n                  <jats:p>\n                    A prospective, randomised, placebo-controlled crossover study was performed. In total, 30 consecutive newly diagnosed OSA patients (apnoea\/hypopnoea index 43.8\u00b127.0\u2005events\u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and 15 healthy obese patients were selected. Urinary levels of norepinephrine and epinephrine, as well as plasma sTNFR-1, tumour necrosis factor (TNF)-\u03b1, interleukin (IL)-6 and leukotriene (LT)B\n                    <jats:sub>4<\/jats:sub>\n                    levels were obtained at baseline and after 3\u2005months of CPAP or sham CPAP.\n                  <\/jats:p>\n                  <jats:p>\n                    Nocturnal urinary levels of norepinephrine, epinephrine and sTNFR-1 (1,053\u00b1269\n                    <jats:italic>versus<\/jats:italic>\n                    820\u00b1166\u2005pg\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) were significantly higher in OSA patients. There were no significant differences in plasma levels of IL-6, LTB\n                    <jats:sub>4<\/jats:sub>\n                    , or TNF-\u03b1 between the two study groups. There were no significant differences in blood pressure, urinary catecholamine levels, or plasma IL-6, LTB\n                    <jats:sub>4<\/jats:sub>\n                    and TNF-\u03b1 levels after both treatment modalities. However, after 3\u2005months of effective CPAP usage, sTNFR-1 levels were significantly reduced (1,053\u00b1269\n                    <jats:italic>versus<\/jats:italic>\n                    899\u00b1254\u2005pg\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ).\n                  <\/jats:p>\n                  <jats:p>Obstructive sleep apnoea patients have higher levels of soluble tumour necrosis factor-\u03b1 receptor 1 than individuals without OSA; soluble tumour necrosis factor-\u03b1 receptor 1 levels are lowered by continuous positive airway pressure therapy. These findings further corroborate a potential role of inflammation in the natural history of obstructive sleep apnoea.<\/jats:p>","DOI":"10.1183\/09031936.00007008","type":"journal-article","created":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T20:26:11Z","timestamp":1212006371000},"page":"1009-1015","source":"Crossref","is-referenced-by-count":96,"title":["CPAP decreases plasma levels of soluble tumour necrosis factor-\u03b1 receptor 1 in obstructive sleep apnoea"],"prefix":"10.1183","volume":"32","author":[{"given":"M. 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