{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:18:43Z","timestamp":1790756323404,"version":"4.1.0"},"reference-count":31,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,11,13]]},"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Severity of respiratory syncytial virus (RSV) infection ranges widely. To what extent the local immune response is involved in RSV disease pathogenesis and which markers of this response are critical in determining disease severity is still a matter of debate.<\/jats:p><jats:p>The local immune response was studied in nasopharyngeal aspirates (NPAs) during RSV infection. 47 potential markers of disease severity were analysed in a screening cohort of RSV-infected infants with mild disease at home (n=8), hospitalised infants (n=10) and infants requiring mechanical ventilation (n=7). Results were confirmed in a cohort of infants hospitalised for RSV infection (n=200). Finally, genetic validation was studied in a cohort of infants hospitalised for RSV infection (n=465) and healthy controls (n=930).<\/jats:p><jats:p>The concentration of TIMP-1 (tissue inhibitor of metalloproteinase) was higher in the NPAs of hospitalised infants compared with the NPAs of infants at home (1,199<jats:italic>versus<\/jats:italic>568 ng\u00b7mL<jats:sup>\u22121<\/jats:sup>; p&lt;0.0001). Similar results were found for matrix metalloproteinase (MMP)-3 (765<jats:italic>versus<\/jats:italic>370 pg\u00b7mL<jats:sup>\u22121<\/jats:sup>; p=0.004). MMP-3 was confirmed as a marker of disease severity in a larger cohort and<jats:italic>MMP3<\/jats:italic>gene polymorphism rs522616 was associated with severe RSV infection (OR 0.82, p&lt;0.05).<\/jats:p><jats:p>In conclusion, extracellular matrix proteinases play an important role in the pathogenesis of RSV bronchiolitis.<\/jats:p>","DOI":"10.1183\/09031936.00012311","type":"journal-article","created":{"date-parts":[[2012,1,21]],"date-time":"2012-01-21T06:00:05Z","timestamp":1327125605000},"page":"1475-1481","source":"Crossref","is-referenced-by-count":22,"title":["Proteins involved in extracellular matrix dynamics are associated with respiratory syncytial virus disease severity"],"prefix":"10.1183","volume":"39","author":[{"given":"Annemieke","family":"Schuurhof","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Bont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hennie M.","family":"Hodemaekers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arja","family":"de Klerk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke","family":"de Groot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina W.","family":"Hofland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma C.","family":"van de Pol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan L.L.","family":"Kimpen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riny","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2012,1,20]]},"reference":[{"key":"2024102020582472000_39.6.1475.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.15.1440"},{"key":"2024102020582472000_39.6.1475.2","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/61.1.13"},{"key":"2024102020582472000_39.6.1475.3","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.110531"},{"key":"2024102020582472000_39.6.1475.4","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0140-6736(99)02368-5","article-title":"Prophylaxis against respiratory syncytial virus in premature infants","volume":"354","author":"Bont","year":"1999","journal-title":"Lancet"},{"key":"2024102020582472000_39.6.1475.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)80040-3"},{"key":"2024102020582472000_39.6.1475.6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0788"},{"key":"2024102020582472000_39.6.1475.7","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21771"},{"key":"2024102020582472000_39.6.1475.8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00097-10"},{"key":"2024102020582472000_39.6.1475.9","doi-asserted-by":"publisher","DOI":"10.1086\/322035"},{"key":"2024102020582472000_39.6.1475.10","doi-asserted-by":"publisher","DOI":"10.1086\/520886"},{"key":"2024102020582472000_39.6.1475.11","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/ppul.21229","article-title":"Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls","volume":"45","author":"Schuurhof","year":"2010","journal-title":"Pediatr Pulmonol"},{"key":"2024102020582472000_39.6.1475.12","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31818e2aa9"},{"key":"2024102020582472000_39.6.1475.13","unstructured":"Viet AL van denHof S Elvers LH . Risk factors and health in the Netherlands, a survey by municipal public; annual report 2001. RIVM report 260854004. Bilthoven, National Institute for Public Health and the Environment, 2003."},{"key":"2024102020582472000_39.6.1475.14","doi-asserted-by":"publisher","DOI":"10.1086\/345859"},{"key":"2024102020582472000_39.6.1475.15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testin","volume":"57","author":"Bemjamini","year":"1995","journal-title":"J R Stat Soc B"},{"key":"2024102020582472000_39.6.1475.16","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10296"},{"key":"2024102020582472000_39.6.1475.17","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900373"},{"key":"2024102020582472000_39.6.1475.18","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20830"},{"key":"2024102020582472000_39.6.1475.19","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2006"},{"key":"2024102020582472000_39.6.1475.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.12.082"},{"key":"2024102020582472000_39.6.1475.21","doi-asserted-by":"publisher","DOI":"10.1002\/path.1400"},{"key":"2024102020582472000_39.6.1475.22","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00047-08"},{"key":"2024102020582472000_39.6.1475.23","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00063"},{"key":"2024102020582472000_39.6.1475.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(99)00279-4"},{"key":"2024102020582472000_39.6.1475.25","doi-asserted-by":"publisher","DOI":"10.1080\/00365540600702058"},{"key":"2024102020582472000_39.6.1475.26","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.661-665.2005"},{"key":"2024102020582472000_39.6.1475.27","doi-asserted-by":"publisher","DOI":"10.1007\/s705-002-8316-1"},{"key":"2024102020582472000_39.6.1475.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2007.04.003"},{"key":"2024102020582472000_39.6.1475.29","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.116061"},{"key":"2024102020582472000_39.6.1475.30","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2470-7"},{"key":"2024102020582472000_39.6.1475.31","doi-asserted-by":"publisher","DOI":"10.1086\/428855"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00012311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:35:09Z","timestamp":1740378909000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00012311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,20]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,5,31]]},"published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1183\/09031936.00012311"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00012311","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,20]]}}}