{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:40:35Z","timestamp":1793043635769,"version":"4.5.0"},"reference-count":23,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2007,5,7]]},"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>Bronchial biopsy specimens from chronic obstructive pulmonary disease (COPD) patients demonstrate increased numbers of CD8+ T-lymphocytes, macrophages and, in some studies, neutrophils and eosinophils. Smoking cessation affects the rate of forced expiratory volume in one second (FEV<jats:sub>1<\/jats:sub>) decline in COPD, but the effect on inflammation is uncertain. Bronchial biopsy inflammatory cell counts were compared in current and ex-smokers with COPD.<\/jats:p><jats:p>A pooled analysis of subepithelial inflammatory cell count data from three bronchial biopsy studies that included COPD patients who were either current or ex-smokers was performed.<\/jats:p><jats:p>Cell count data from 101 subjects, 65 current smokers and 36 ex-smokers, were analysed for the following cell types: CD4+ and CD8+ T-lymphocytes, CD68+ (monocytes\/macrophages), neutrophil elastase+ (neutrophils), EG2+ (eosinophils), mast cell tryptase+ and cells mRNA-positive for tumour necrosis factor-\u03b1. Current smokers and ex-smokers were similar in terms of lung function, as measured by FEV<jats:sub>1<\/jats:sub>(% predicted), forced vital capacity (FVC) and FEV<jats:sub>1<\/jats:sub>\/FVC. The results demonstrate that there were no significant differences between smokers and ex-smokers in the numbers of any of the inflammatory cell types or markers analysed.<\/jats:p><jats:p>It is concluded that, in established chronic obstructive pulmonary disease, the bronchial mucosal inflammatory cell infiltrate is similar in ex-smokers and those that continue to smoke.<\/jats:p>","DOI":"10.1183\/09031936.00013006","type":"journal-article","created":{"date-parts":[[2007,5,16]],"date-time":"2007-05-16T00:39:46Z","timestamp":1179275986000},"page":"467-471","source":"Crossref","is-referenced-by-count":130,"title":["Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis"],"prefix":"10.1183","volume":"30","author":[{"given":"E.","family":"Gamble","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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