{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:30:57Z","timestamp":1788827457320,"version":"build-2803163510"},"reference-count":26,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2008,10,27]]},"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p>The aim of the present study was to evaluate the<jats:italic>in vivo<\/jats:italic>regulation of cyclooxygenase-2 in nasal polyps.<\/jats:p><jats:p>In total, 65 patients with nasal polyps were randomly (3:1) treated with (n\u200a=\u200a51; 33 with asthma) or without (n\u200a=\u200a14) oral prednisone and intranasal budesonide for 2\u2005weeks plus intranasal budesonide for 10 additional weeks. Biopsies were obtained at baseline and after 2 and 12\u2005weeks of treatment. All samples were analysed for cyclooxygenase-1 and cyclooxygenase-2 mRNA. Attempts were made to detect cyclooxygenase-2 protein.<\/jats:p><jats:p>At baseline, cyclooxygenase-1 and cyclooxygenase-2 expression did not differ between polyps from nonasthmatic and asthmatic patients. Cyclooxygenase-1 mRNA was unchanged by glucocorticoid treatment, while cyclooxygenase-2 mRNA increased in glucocorticoid-treated patients at week 2 compared with baseline and then decreased at week 12. Within subgroups, increased cyclooxygenase-2 mRNA was found at week 2 in polyps from nonasthmatic and asthmatic patients compared with baseline. At week 12, cyclooxygenase-2 expression remained high in nonasthmatics while it decreased in asthmatics. Cyclooxygenase-2 protein was not detected under any circumstances.<\/jats:p><jats:p>Glucocorticoid therapy enhances cyclooxygenase-2 expression<jats:italic>in vivo<\/jats:italic>in nasal polyps, a finding that does not follow the generally accepted assumption that cyclooxygenase-2 expression is suppressed by glucocorticoids.<\/jats:p>","DOI":"10.1183\/09031936.00017408","type":"journal-article","created":{"date-parts":[[2008,11,15]],"date-time":"2008-11-15T01:34:44Z","timestamp":1226712884000},"page":"502-508","source":"Crossref","is-referenced-by-count":13,"title":["Glucocorticoid therapy increases COX-2 gene expression in nasal polyps<i>in 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