{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:30:13Z","timestamp":1790645413418,"version":"4.1.0"},"reference-count":28,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2013,5,10]]},"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>The 22 risk factors suggested by the Centers for Disease Control and Prevention (CDC) to predict patients at risk for<jats:italic>Mycobacterium tuberculosis<\/jats:italic>have not been evaluated in hospitalised patients with community-acquired pneumonia (CAP). We evaluated which of the CDC risk factors best predict<jats:italic>M. tuberculosis<\/jats:italic>in these patients. To our knowledge, this is the first time a score has been developed assessing these risk factors.<\/jats:p><jats:p>This was a secondary analysis of 6976 patients hospitalised with CAP enrolled in the Community-Acquired Pneumonia Organization International Cohort Study. Using Poisson regression, we selected the subset of risk factors that best predicted the presence of CAP due to<jats:italic>M. tuberculosis<\/jats:italic>. This subset was compared to the CDC risk factors using receiver operating characteristic (ROC) curve analysis.<\/jats:p><jats:p>Five risk factors were found to best predict CAP due to<jats:italic>M. tuberculosis<\/jats:italic>: night sweats, haemoptysis, weight loss,<jats:italic>M. tuberculosis<\/jats:italic>exposure and upper lobe infiltrate. The area under the ROC curve for all CDC risk factors was 71% and 89% for the subset of five risk factors.<\/jats:p><jats:p>The CDC-suggested risk factors are poor at predicting the presence of<jats:italic>M. tuberculosis<\/jats:italic>in hospitalised patients with CAP. With a subset of five risk factors identified in this study, we developed a new score, which will improve our capacity to isolate patients at risk of CAP due to<jats:italic>M. tuberculosis<\/jats:italic>at the time of hospitalisation.<\/jats:p>","DOI":"10.1183\/09031936.00017813","type":"journal-article","created":{"date-parts":[[2013,6,22]],"date-time":"2013-06-22T03:17:43Z","timestamp":1371871063000},"page":"178-184","source":"Crossref","is-referenced-by-count":23,"title":["Predicting<i>Mycobacterium tuberculosis<\/i>in patients with community-acquired pneumonia"],"prefix":"10.1183","volume":"43","author":[{"given":"Rodrigo","family":"Cavallazzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Wiemken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Peyrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Blasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gur","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Aliberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Community-Acquired Pneumonia Organization (CAPO) Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"key":"2024102021421019000_43.1.178.1","unstructured":"World Health Organization. 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