{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:12:08Z","timestamp":1758474728955,"version":"3.37.3"},"reference-count":22,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,3,22]]},"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>The diagnostic value of flexible bronchoscopy in the pre-operative work-up of solitary pulmonary nodules (SPN) is still under debate among pneumologists, radiologists and thoracic surgeons.<\/jats:p><jats:p>In a prospective observational manner, flexible bronchoscopy was routinely performed in 225 patients with SPN of unknown origin.<\/jats:p><jats:p>Of the 225 patients, 80.5% had lung cancer, 7.6% had metastasis of an extrapulmonary primary tumour and 12% had benign aetiology. Unsuspected endobronchial involvement was found in 4.4% of all 225 patients (or in 5.5% of patients with lung cancer). In addition, flexible bronchoscopy clarified the underlying aetiology in 41% of the cases. The bronchoscopic biopsy results from the SPN were positive in 84 (46.5%) patients with lung cancer. Surgery was cancelled due to the results of flexible bronchoscopy in four cases (involvement of the right main bronchus (impaired pulmonary function did not allow pneumonectomy) n=1, small cell lung cancer n=1, bacterial pneumonia n=2), and the surgical strategy had to be modified to bilobectomy in one patient.<\/jats:p><jats:p>Flexible bronchoscopy changed the planned surgical approach in five cases substantially. These results suggest that routine flexible bronchoscopy should be included in the regular pre-operative work-up of patients with SPN.<\/jats:p>","DOI":"10.1183\/09031936.00018612","type":"journal-article","created":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T01:07:11Z","timestamp":1334106431000},"page":"177-182","source":"Crossref","is-referenced-by-count":17,"title":["Value of flexible bronchoscopy in the pre-operative work-up of solitary pulmonary nodules"],"prefix":"10.1183","volume":"41","author":[{"given":"Carsten","family":"Schwarz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Sch\u00f6nfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland C.","family":"Bittner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Mairinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"R\u00fcssmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten T.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Loddenkemper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2012,4,10]]},"reference":[{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.1","DOI":"10.2214\/AJR.05.1229"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.2","DOI":"10.1378\/chest.07-1352"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.3","DOI":"10.1378\/chest.07-1353"},{"key":"2024102021061865000_41.1.177.4","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1378\/chest.104.4.1021","article-title":"The utility of fiberoptic bronchoscopy in the evaluation of the solitary pulmonary nodule","volume":"104","author":"Torrington","year":"1993","journal-title":"Chest"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.5","DOI":"10.1378\/chest.104.1.94"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.6","DOI":"10.1055\/s-0030-1255961"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.7","DOI":"10.1378\/chest.108.1.131"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.8","DOI":"10.1378\/chest.116.3.704"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.9","DOI":"10.1378\/chest.129.1.147"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.10","DOI":"10.1378\/chest.08-0577"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.11","DOI":"10.1111\/j.1440-1843.2011.02026.x"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.12","DOI":"10.1183\/09031936.00075310"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.13","DOI":"10.1378\/chest.113.5.1244"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.14","DOI":"10.1378\/chest.128.5.3558"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.15","DOI":"10.1378\/chest.07-1360"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.16","DOI":"10.1016\/j.suc.2010.10.012"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.17","DOI":"10.1136\/thx.2010.154476"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.18","DOI":"10.7326\/0003-4819-151-4-200908180-00132"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.19","DOI":"10.1200\/JCO.2004.04.126"},{"doi-asserted-by":"publisher","key":"2024102021061865000_41.1.177.20","DOI":"10.1016\/j.athoracsur.2010.08.054"},{"key":"2024102021061865000_41.1.177.21","first-page":"1","article-title":"Management of SPN in France. 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