{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:28:43Z","timestamp":1770985723033,"version":"3.50.1"},"reference-count":24,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2008,7,14]]},"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p>Fluticasone propionate reduces the frequency and severity of the episodes of exacerbation of chronic obstructive pulmonary disease (COPD).<jats:italic>Streptococcus pneumoniae<\/jats:italic>and<jats:italic>Haemophilus influenzae<\/jats:italic>are frequently isolated in these episodes. Both express phosphorylcholine, an epitope that mediates their interaction with airway epithelial cells<jats:italic>via<\/jats:italic>the platelet-activating factor receptor (PAFR).<\/jats:p><jats:p>The present work studies the effects of fluticasone propionate on the expression of PAFR on human airway epithelial cells, the invasion of these cells by<jats:italic>S. pneumoniae<\/jats:italic>and<jats:italic>H. influenzae<\/jats:italic>, and the course of pneumococcal infection<jats:italic>in vivo<\/jats:italic>. The following were used in the experiments:<jats:italic>S. pneumoniae<\/jats:italic>and<jats:italic>H. influenzae<\/jats:italic>isolated from patients with COPD, cell cultures of type II pneumocytes and bronchoepithelial cells, and a mouse model of lung infection.<\/jats:p><jats:p>Fluticasone propionate was found to reduce PAFR expression on the surface of the two cells types studied. All<jats:italic>S. pneumoniae<\/jats:italic>and<jats:italic>H. influenzae<\/jats:italic>isolates expressed phosphorylcholine. Treatment of both cells lines with fluticasone propionate reduced invasion of both microorganisms and reduced the bacterial load of mice infected with<jats:italic>S. pneumoniae<\/jats:italic>.<\/jats:p><jats:p>Fluticasone propionate reduces the invasion of airway epithelial cells by<jats:italic>Streptococcus pneumoniae<\/jats:italic>and<jats:italic>Haemophilus influenzae<\/jats:italic>through its effect on platelet-activating factor receptor. These results may help explain the beneficial effects of fluticasone propionate on chronic obstructive pulmonary disease exacerbations.<\/jats:p>","DOI":"10.1183\/09031936.00020608","type":"journal-article","created":{"date-parts":[[2008,8,7]],"date-time":"2008-08-07T00:54:11Z","timestamp":1218070451000},"page":"1283-1288","source":"Crossref","is-referenced-by-count":27,"title":["Fluticasone propionate reduces bacterial airway epithelial invasion"],"prefix":"10.1183","volume":"32","author":[{"given":"M.","family":"Barbier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Agust\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Albert\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2008,8,6]]},"reference":[{"key":"2024102019405508000_32.5.1283.1","unstructured":"Global Initiative for Chronic Obstructive Lung Diseases. 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