{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:22:02Z","timestamp":1789384922843,"version":"build-2803163510"},"reference-count":20,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2007,5,14]]},"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>The aim of this study was to assess the contribution of an interferon-\u03b3 release assay (T-SPOT.<jats:italic>TB<\/jats:italic>) to the differentiation of active tuberculosis (TB) from latent TB infection by quantifying spot-forming units (sfu).<\/jats:p><jats:p>The investigation was a prospective study of contacts exposed to a case of contagious TB and cases of HIV-negative culture-proven TB referred over a 16-month period. Tuberculin skin tests (TSTs) and T-SPOT.<jats:italic>TB<\/jats:italic>were performed in 310 contacts 8\u201312\u2005weeks after exposure. In subjects with culture-proven TB, T-SPOT.<jats:italic>TB<\/jats:italic>was performed within 2\u2005weeks of initiation of treatment. The analysis included all contacts with a positive T-SPOT.<jats:italic>TB<\/jats:italic>result and all subjects with TB.<\/jats:p><jats:p>TB contacts (n\u200a=\u200a127) and cases (n\u200a=\u200a58) were included. Mean\u00b1<jats:sc>sd<\/jats:sc>T-SPOT.<jats:italic>TB<\/jats:italic>results were 107\u00b156 (range 1\u2013207)\u2005sfu for TB, 54\u00b160 (7\u2013239)\u2005sfu for contacts with positive T-SPOT.<jats:italic>TB<\/jats:italic>results and a TST induration diameter of &gt;5\u2005mm, and 19\u00b127 (7\u2013143)\u2005sfu for contacts with positive T-SPOT.<jats:italic>TB<\/jats:italic>results and a TST induration diameter of \u22645\u2005mm. By receiver operating characteristic curve analysis, a threshold value of 49.5\u2005sfu showed a sensitivity of 83% and specificity of 74% for distinguishing latent TB infection from TB.<\/jats:p><jats:p>Although T-SPOT.<jats:italic>TB<\/jats:italic>results were significantly related to disease activity, the test cannot be recommended for the diagnosis of tuberculosis.<\/jats:p>","DOI":"10.1183\/09031936.00028507","type":"journal-article","created":{"date-parts":[[2007,5,31]],"date-time":"2007-05-31T00:19:24Z","timestamp":1180570764000},"page":"722-728","source":"Crossref","is-referenced-by-count":84,"title":["Quantitative scoring of an interferon-\u03b3 assay for differentiating active from latent tuberculosis"],"prefix":"10.1183","volume":"30","author":[{"given":"J-P.","family":"Janssens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Roux-Lombard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Perneger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Metzger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Vivien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Rochat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2007,5,30]]},"reference":[{"key":"2024102019185464000_30.4.722.1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00107005"},{"key":"2024102019185464000_30.4.722.2","doi-asserted-by":"publisher","DOI":"10.1086\/509927"},{"key":"2024102019185464000_30.4.722.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200509-1516PP"},{"key":"2024102019185464000_30.4.722.4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200505-748OC"},{"key":"2024102019185464000_30.4.722.5","first-page":"1242","volume":"9","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"2024102019185464000_30.4.722.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05115-1"},{"key":"2024102019185464000_30.4.722.7","unstructured":"Mazurek GH, Jereb J, LoBue P, Iademarco MF, Metchock B, Vernon A. 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