{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:56:39Z","timestamp":1781852199304,"version":"3.54.5"},"reference-count":15,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2008,3,14]]},"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>No information is currently available on the influence of injectable second-line drugs on treatment outcomes of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) patients.<\/jats:p><jats:p>To investigate this issue, a large series of MDR- and XDR-TB cases diagnosed in Estonia, Germany, Italy and the Russian Federation (Archangels Oblast) between 1999 and 2006 were analysed. All study sites performed drug susceptibility testing for first- and second-line anti-TB drugs, laboratory quality assurance and treatment delivery according to World Health Organization recommendations.<\/jats:p><jats:p>Out of 4,583 culture-confirmed cases, 240 MDR- and 48 XDR-TB cases had a definitive outcome recorded (treatment success, death, failure). Among MDR- and XDR-TB cases, capreomycin resistance yielded a higher proportion of failure and death than capreomycin-susceptible cases. Resistance to capreomycin was independently associated with unfavourable outcome (logistic regression analysis: odds ratio 3.51).<\/jats:p><jats:p>In the treatment of patients with multidrug-resistant and extensively drug-resistant tuberculosis, resistance to the injectable drug capreomycin was an independent predictor for therapy failure in this cohort. As<jats:italic>Mycobacterium tuberculosis<\/jats:italic>drug resistance is increasing worldwide, there is an urgent need for novel interventions in the fight against tuberculosis.<\/jats:p>","DOI":"10.1183\/09031936.00028708","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T17:40:40Z","timestamp":1212169240000},"page":"1155-1159","source":"Crossref","is-referenced-by-count":105,"title":["Resistance to second-line injectables and treatment outcomes in multidrug-resistant and extensively drug-resistant tuberculosis cases"],"prefix":"10.1183","volume":"31","author":[{"given":"G. 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