{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:29:46Z","timestamp":1773923386811,"version":"3.50.1"},"reference-count":49,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2006,8,29]]},"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>Respiratory syncytial virus (RSV) bronchiolitis is the most common lower respiratory tract infection in infancy. To date, there is no effective therapy for RSV bronchiolitis.<\/jats:p>\n                  <jats:p>In order to investigate the efficacy of clarithromycin in the treatment of RSV bronchiolitis, the present authors conducted a randomised, double-blind, placebo-controlled trial comparing clarithromycin with placebo in 21 infants with a diagnosis of RSV bronchiolitis. The infants were randomised to receive clarithromycin or placebo daily for 3\u2005weeks. Levels of interleukin (IL)-4, IL-8, eotaxin, and interferon-\u03b3 were determined in plasma, before and after treatment, using ELISA. Six months after treatment, parents were surveyed as to whether their child had experienced wheezing within the previous 6\u2005months.<\/jats:p>\n                  <jats:p>\n                    Treatment with clarithromycin was associated with a statistically significant reduction in the length of hospital stay, the duration of need for supplemental oxygen and the need for \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    -agonist treatment. There were significant decreases in plasma IL-4, IL-8 and eotaxin levels after 3\u2005weeks of treatment with clarithromycin. Readmission to the hospital within 6\u2005months after discharge was significantly lower in the clarithromycin group.\n                  <\/jats:p>\n                  <jats:p>In conclusion, clarithromycin has statistically significant effects on the clinical and laboratory findings in respiratory syncytial virus bronchiolitis. Therefore, clarithromycin treatment may be helpful in reducing the short-term effects of respiratory syncytial virus bronchiolitis.<\/jats:p>","DOI":"10.1183\/09031936.00029206","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T20:13:38Z","timestamp":1161202418000},"page":"91-97","source":"Crossref","is-referenced-by-count":83,"title":["Clarithromycin in the treatment of RSV bronchiolitis: a double-blind, randomised, placebo-controlled trial"],"prefix":"10.1183","volume":"29","author":[{"given":"F.","family":"Tahan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ozcan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Koc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2006,10,18]]},"reference":[{"key":"2024102019095683000_29.1.91.1","unstructured":"Phelan P, Olinsky A, Robertson C. 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