{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:08:28Z","timestamp":1791022108605,"version":"4.1.0"},"reference-count":74,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,4,30]]},"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) comprise a spectrum of acute inflammatory pulmonary oedema resulting in refractory hypoxaemia in the absence of an underlying cardiogenic cause. There are multiple pulmonary and extrapulmonary causes and ALI\/ARDS patients are a clinically heterogeneous group with associated high morbidity and mortality.<\/jats:p><jats:p>Inflammatory injury to the alveolar epithelial and endothelial capillary membrane is a central event in the pathogenesis of ALI\/ARDS, and involves degradation of the basement membrane. Matrix metalloproteinases (MMPs) have been implicated in a wide variety of pulmonary pathologies and are capable of degrading all components of the extracellular matrix including the basement membrane and key non-matrix mediators of lung injury such as chemokines and cell surface receptors.<\/jats:p><jats:p>While many studies implicate MMPs in the injurious process, there are significant gaps in our knowledge of the role of specific proteases at different phases of injury and repair. This article examines the role of MMPs in injury and repair of the alveolar epithelial\u2013endothelial capillary barrier and discusses the potential for MMP modulation in the prevention and treatment of ALI. The need for further mechanistic and<jats:italic>in vivo<\/jats:italic>studies to inform appropriate subsequent clinical trials of MMP modulation will be highlighted.<\/jats:p>","DOI":"10.1183\/09031936.00032111","type":"journal-article","created":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T01:16:01Z","timestamp":1305249361000},"page":"959-970","source":"Crossref","is-referenced-by-count":231,"title":["Matrix metalloproteinases in acute lung injury: mediators of injury and drivers of repair"],"prefix":"10.1183","volume":"38","author":[{"given":"A.","family":"Davey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.F.","family":"McAuley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.M.","family":"O'Kane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2011,5,12]]},"reference":[{"key":"2024102020392796000_38.4.959.1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.7509706"},{"key":"2024102020392796000_38.4.959.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421806"},{"key":"2024102020392796000_38.4.959.3","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.48.1741"},{"key":"2024102020392796000_38.4.959.4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130158"},{"key":"2024102020392796000_38.4.959.5","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.F305"},{"key":"2024102020392796000_38.4.959.6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6113.631"},{"key":"2024102020392796000_38.4.959.7","first-page":"391","article-title":"The structure and function of the lung","volume":"14","author":"Murray","year":"2010","journal-title":"Int J Tuberc Lung Dis"},{"key":"2024102020392796000_38.4.959.8","first-page":"L3","article-title":"Extracellular matrix biology in the lung","volume":"270","author":"Dunsmore","year":"1996","journal-title":"Am J Physiol"},{"key":"2024102020392796000_38.4.959.9","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2006"},{"key":"2024102020392796000_38.4.959.10","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.20065"},{"key":"2024102020392796000_38.4.959.11","unstructured":"O'Kane CM Frank J McAuley DF . Matrix metalloproteinases: a potential role in the pathogenesis of ARDS. In: Vincent JL , ed. Yearbook of Intensive Care and Emergency Medicine. 1st Edn. Heidelberg, Springer, 2004; pp. 287\u2013300."},{"key":"2024102020392796000_38.4.959.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00248-9"},{"key":"2024102020392796000_38.4.959.13","doi-asserted-by":"publisher","DOI":"10.1101\/gad.815400"},{"key":"2024102020392796000_38.4.959.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2007.07.003"},{"key":"2024102020392796000_38.4.959.15","doi-asserted-by":"publisher","DOI":"10.1038\/nri1418"},{"key":"2024102020392796000_38.4.959.16","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2125"},{"key":"2024102020392796000_38.4.959.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2004.07.010"},{"key":"2024102020392796000_38.4.959.18","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.051979"},{"key":"2024102020392796000_38.4.959.19","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787846587"},{"key":"2024102020392796000_38.4.959.20","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181a5506c"},{"key":"2024102020392796000_38.4.959.21","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.00049201"},{"key":"2024102020392796000_38.4.959.22","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000238342.16081.f9"},{"key":"2024102020392796000_38.4.959.23","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2009.50.1.68"},{"key":"2024102020392796000_38.4.959.24","doi-asserted-by":"publisher","DOI":"10.1191\/0267659103pf662oa"},{"key":"2024102020392796000_38.4.959.25","doi-asserted-by":"publisher","DOI":"10.1111\/j.0959-9673.2004.00385.x"},{"key":"2024102020392796000_38.4.959.26","first-page":"L442","article-title":"Gelatinases in epithelial lining fluid of patients with adult respiratory distress syndrome","volume":"272","author":"Delclaux","year":"1997","journal-title":"Am J Physiol"},{"key":"2024102020392796000_38.4.959.27","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199902000-00036"},{"key":"2024102020392796000_38.4.959.28","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000048626.02184.F8"},{"key":"2024102020392796000_38.4.959.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.11.023"},{"key":"2024102020392796000_38.4.959.30","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200810-1584OC"},{"key":"2024102020392796000_38.4.959.31","doi-asserted-by":"publisher","DOI":"10.1136\/fn.84.3.F168"},{"key":"2024102020392796000_38.4.959.32","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.3.686"},{"key":"2024102020392796000_38.4.959.33","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1651-2227.2004.tb03020.x","article-title":"The role of matrix metalloproteinases -9 and -2 in development of neonatal chronic lung disease","volume":"93","author":"Sweet","year":"2004","journal-title":"Acta Paediatr"},{"key":"2024102020392796000_38.4.959.34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.7150\/ijms.6.9","article-title":"Matrix metalloproteinase activity in paediatric acute lung injury","volume":"6","author":"Kong","year":"2009","journal-title":"Int J Med Sci"},{"key":"2024102020392796000_38.4.959.35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00047.2010"},{"key":"2024102020392796000_38.4.959.36","doi-asserted-by":"publisher","DOI":"10.2174\/138161207779313551"},{"key":"2024102020392796000_38.4.959.37","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00270.2005"},{"key":"2024102020392796000_38.4.959.38","doi-asserted-by":"publisher","DOI":"10.1186\/1477-5956-8-3"},{"key":"2024102020392796000_38.4.959.39","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2001.6180"},{"key":"2024102020392796000_38.4.959.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-4804(03)00089-1"},{"key":"2024102020392796000_38.4.959.41","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.4.400"},{"key":"2024102020392796000_38.4.959.42","doi-asserted-by":"publisher","DOI":"10.1159\/000212080"},{"key":"2024102020392796000_38.4.959.43","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1165\/ajrcmb.25.6.4558f","article-title":"Ventilator-induced lung injury upregulates and activates gelatinases and EMMPRIN: attenuation by the synthetic matrix metalloproteinase inhibitor, Prinomastat (AG3340)","volume":"25","author":"Foda","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2024102020392796000_38.4.959.44","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-4804(02)00084-7"},{"key":"2024102020392796000_38.4.959.45","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.30348"},{"key":"2024102020392796000_38.4.959.46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11523"},{"key":"2024102020392796000_38.4.959.47","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.4049\/jimmunol.162.6.3653","article-title":"Regulatory effects of endogenous protease inhibitors in acute lung inflammatory injury","volume":"162","author":"Gipson","year":"1999","journal-title":"J Immunol"},{"key":"2024102020392796000_38.4.959.48","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/01.ta.0000200075.12489.74","article-title":"LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-\u03baB, and ICAM-1 expression","volume":"60","author":"Coimbra","year":"2006","journal-title":"J Trauma"},{"key":"2024102020392796000_38.4.959.49","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.12.2104017"},{"key":"2024102020392796000_38.4.959.50","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31802d96cb"},{"key":"2024102020392796000_38.4.959.51","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00441.2007"},{"key":"2024102020392796000_38.4.959.52","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.24.5.4160"},{"key":"2024102020392796000_38.4.959.53","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0179OC"},{"key":"2024102020392796000_38.4.959.54","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00334.2007"},{"key":"2024102020392796000_38.4.959.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2007.04.003"},{"key":"2024102020392796000_38.4.959.56","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01079-6"},{"key":"2024102020392796000_38.4.959.57","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0111OC"},{"key":"2024102020392796000_38.4.959.58","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.12.7791"},{"key":"2024102020392796000_38.4.959.59","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900290"},{"key":"2024102020392796000_38.4.959.60","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0034OC"},{"key":"2024102020392796000_38.4.959.61","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00361.2009"},{"key":"2024102020392796000_38.4.959.62","first-page":"730","article-title":"Lung parenchyma remodeling in acute respiratory distress syndrome","volume":"75","author":"Rocco","year":"2009","journal-title":"Minerva Anestesiol"},{"key":"2024102020392796000_38.4.959.63","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420729"},{"key":"2024102020392796000_38.4.959.64","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0963-x"},{"key":"2024102020392796000_38.4.959.65","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1164\/ajrccm.164.6.2007062","article-title":"Lung tissue mechanics and extracellular matrix remodeling in acute lung injury","volume":"164","author":"Rocco","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102020392796000_38.4.959.66","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00395.2005"},{"key":"2024102020392796000_38.4.959.67","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00266"},{"key":"2024102020392796000_38.4.959.68","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.5.2001061"},{"key":"2024102020392796000_38.4.959.69","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-0043-z"},{"key":"2024102020392796000_38.4.959.70","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.08.005"},{"key":"2024102020392796000_38.4.959.71","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64318-0"},{"key":"2024102020392796000_38.4.959.72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006565"},{"key":"2024102020392796000_38.4.959.73","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070891"},{"key":"2024102020392796000_38.4.959.74","doi-asserted-by":"crossref","first-page":"L427","DOI":"10.1152\/ajplung.2001.281.2.L427","article-title":"Migration and gelatinases in cultured fetal, adult, and hyperoxic alveolar epithelial cells","volume":"281","author":"Buckley","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00032111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:30:18Z","timestamp":1740378618000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00032111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,12]]},"references-count":74,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,9,30]]},"published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1183\/09031936.00032111"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00032111","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,12]]}}}