{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:34:48Z","timestamp":1793932488689,"version":"4.8.0"},"reference-count":38,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":["ersjournals.com"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2014,7,12]]},"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Although commonly observed in clinical practice, the heterogeneity of obstructive sleep apnoea (OSA) clinical presentation has not been formally characterised.<\/jats:p><jats:p>This study was the first to apply cluster analysis to identify subtypes of patients with OSA who experience distinct combinations of symptoms and comorbidities. An analysis of baseline data from the Icelandic Sleep Apnoea Cohort (822 patients with newly diagnosed moderate-to-severe OSA) was performed.<\/jats:p><jats:p>Three distinct clusters were identified. They were classified as the \u201cdisturbed sleep group\u201d (cluster 1), \u201cminimally symptomatic group\u201d (cluster 2) and \u201cexcessive daytime sleepiness group\u201d (cluster 3), consisting of 32.7%, 24.7% and 42.6% of the entire cohort, respectively. The probabilities of having comorbid hypertension and cardiovascular disease were highest in cluster 2 but lowest in cluster 3. The clusters did not differ significantly in terms of sex, body mass index or apnoea\u2013hypopnoea index.<\/jats:p><jats:p>Patients with OSA have different patterns of clinical presentation, which need to be communicated to both the lay public and the professional community with the goal of facilitating care-seeking and early identification of OSA. Identifying distinct clinical profiles of OSA creates a foundation for offering more personalised therapies in the future.<\/jats:p>","DOI":"10.1183\/09031936.00032314","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T13:33:01Z","timestamp":1409837581000},"page":"1600-1607","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":446,"title":["The different clinical faces of obstructive sleep apnoea: a cluster analysis"],"prefix":"10.1183","volume":"44","author":[{"given":"Lichuan","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace W.","family":"Pien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Ratcliffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erla","family":"Bj\u00f6rnsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erna Sif","family":"Arnardottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan I.","family":"Pack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryndis","family":"Benediktsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorarinn","family":"Gislason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2014,9,3]]},"reference":[{"key":"2024102023004257000_44.6.1600.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074873"},{"key":"2024102023004257000_44.6.1600.2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070244"},{"key":"2024102023004257000_44.6.1600.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0896OC"},{"key":"2024102023004257000_44.6.1600.4","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.154484"},{"key":"2024102023004257000_44.6.1600.5","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-002795"},{"key":"2024102023004257000_44.6.1600.6","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2012.138"},{"key":"2024102023004257000_44.6.1600.7","first-page":"921","article-title":"The interaction of obstructive sleep apnea and obesity on the inflammatory markers C-reactive protein and interleukin-6: the Icelandic Sleep Apnea Cohort","volume":"35","author":"Arnardottir","year":"2012","journal-title":"Sleep"},{"key":"2024102023004257000_44.6.1600.8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1365-2869.1995.tb00205.x","article-title":"Basic Nordic Sleep Questionnaire (BNSQ): a quantitated measure of subjective sleep complaints","volume":"4","author":"Partinen","year":"1995","journal-title":"J Sleep Res"},{"key":"2024102023004257000_44.6.1600.9","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A new method for measuring daytime sleepiness: the Epworth sleepiness scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"key":"2024102023004257000_44.6.1600.10","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199603000-00003"},{"key":"2024102023004257000_44.6.1600.11","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(03)00010-8"},{"key":"2024102023004257000_44.6.1600.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2011.12.002"},{"key":"2024102023004257000_44.6.1600.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.08.006"},{"key":"2024102023004257000_44.6.1600.14","doi-asserted-by":"crossref","unstructured":"McLachlan GJ Peel D . 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