{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:06:23Z","timestamp":1791317183950,"version":"4.3.1"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2013,7,30]]},"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>The aim of the study was to identify genetic variants associated with refined asthma phenotypes enabling multiple features of the disease to be taken into account.<\/jats:p>\n                  <jats:p>Latent class analysis (LCA) was applied in 3001 adults ever having asthma recruited in the frame of three epidemiological surveys (the European Community Respiratory Health Survey (ECRHS), the Swiss Study on Air Pollution and Lung Disease in Adults (SAPALDIA) and the Epidemiological Study on the Genetics and Environment of Asthma (EGEA)). 14 personal and phenotypic characteristics, gathered from questionnaires and clinical examination, were used. A genome-wide association study was conducted for each LCA-derived asthma phenotype, compared to subjects without asthma (n=3474).<\/jats:p>\n                  <jats:p>\n                    The LCA identified four adult asthma phenotypes, mainly characterised by disease activity, age of asthma onset and atopic status. Associations of genome-wide significance (p&lt;1.25\u00d710\n                    <jats:sup>\u22127<\/jats:sup>\n                    ) were observed between \u201cactive adult-onset nonallergic asthma\u201d and rs9851461 flanking\n                    <jats:italic>CD200<\/jats:italic>\n                    (3q13.2) and between \u201cinactive\/mild nonallergic asthma\u201d and rs2579931 flanking\n                    <jats:italic>GRIK2<\/jats:italic>\n                    (6q16.3). Borderline significant results (2.5\u00d710\n                    <jats:sup>\u22127<\/jats:sup>\n                    &lt;p&lt;8.2\u00d710\n                    <jats:sup>\u22127<\/jats:sup>\n                    ) were observed between three single nucleotide polymorphisms (SNPs) in the\n                    <jats:italic>ALCAM<\/jats:italic>\n                    region (3q13.11) and \u201cactive adult-onset nonallergic asthma\u201d. These results were consistent across studies. 15 SNPs identified in previous genome-wide association studies of asthma have been replicated with at least one asthma phenotype, most of them with the \u201cactive allergic asthma\u201d phenotype.\n                  <\/jats:p>\n                  <jats:p>Our results provide evidence that a better understanding of asthma phenotypic heterogeneity helps to disentangle the genetic heterogeneity of asthma.<\/jats:p>","DOI":"10.1183\/09031936.00032713","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T21:08:36Z","timestamp":1386277716000},"page":"439-452","source":"Crossref","is-referenced-by-count":64,"title":["Genetic heterogeneity of asthma phenotypes identified by a clustering approach"],"prefix":"10.1183","volume":"43","author":[{"given":"Val\u00e9rie","family":"Siroux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan 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