{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:16:00Z","timestamp":1782166560629,"version":"3.54.5"},"reference-count":26,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2013,5,9]]},"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Efficacy and safety of umeclidinium administered in a dry power inhaler were evaluated in moderate-to-very-severe chronic obstructive pulmonary disease patients.<\/jats:p>\n                  <jats:p>\n                    This was a randomised, placebo-controlled study assessing once-daily umeclidinium 62.5 and 125 \u03bcg over 12 weeks. The primary end-point was change from baseline in trough forced expiratory volume in 1 s (FEV\n                    <jats:sub>1<\/jats:sub>\n                    ) on day 85. Secondary end-points were 0\u20136-h weighted mean and serial forced expiratory volume in 1 s. Other end-points were transitional dyspnoea index, health outcomes (St George\u2019s Respiratory Questionnaire), pharmacokinetics and safety.\n                  <\/jats:p>\n                  <jats:p>\n                    246 patients were enrolled; 168 completed the study. On day 85, umeclidinium 62.5 and 125 \u03bcg significantly improved least squares mean change from baseline in trough FEV\n                    <jats:sub>1<\/jats:sub>\n                    (127 and 152 mL, respectively; p&lt;0.001) compared with placebo. On day 84, umeclidinium 62.5 and 125 \u03bcg significantly improved least squares mean change from baseline in 0\u20136-h weighted mean (166 and 191 mL, respectively; p&lt;0.001) and serial FEV\n                    <jats:sub>1<\/jats:sub>\n                    at each time point (p\u22640.003). Significant improvement in least squares mean transitional dyspnoea index focal score (1.0 and 1.3 units, respectively; p\u22640.05) and change from baseline St George\u2019s Respiratory Questionnaire total score (-7.9 and -10.87 units, respectively; p&lt;0.001) were noted compared with placebo at week 12. The incidence of adverse events was low and similar across treatments.\n                  <\/jats:p>\n                  <jats:p>Umeclidinium 62.5 and 125 \u03bcg significantly improved lung function, dyspnoea and health status compared with placebo, and were well tolerated in chronic obstructive pulmonary disease patients over 12 weeks.<\/jats:p>","DOI":"10.1183\/09031936.00033213","type":"journal-article","created":{"date-parts":[[2013,8,15]],"date-time":"2013-08-15T23:27:31Z","timestamp":1376609251000},"page":"72-81","source":"Crossref","is-referenced-by-count":73,"title":["Umeclidinium in patients with COPD: a randomised, placebo-controlled study"],"prefix":"10.1183","volume":"43","author":[{"given":"Roopa","family":"Trivedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Church","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2013,8,15]]},"reference":[{"key":"2024102021500572000_43.1.72.1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. 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ICH Good Clinical Practice guidelines. www.ich.org\/products\/guidelines\/efficacy\/efficacy-single\/article\/good-clinical-practice.html Date last accessed: November 6, 2013."},{"key":"2024102021500572000_43.1.72.14","doi-asserted-by":"publisher","DOI":"10.1378\/chest.85.6.751"},{"key":"2024102021500572000_43.1.72.15","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.6.1321"},{"key":"2024102021500572000_43.1.72.16","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"2024102021500572000_43.1.72.17","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-200050666"},{"key":"2024102021500572000_43.1.72.18","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-200050513"},{"issue":"Suppl. 55","key":"2024102021500572000_43.1.72.19","first-page":"723","article-title":"Safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of GSK573719 in healthy subjects","volume":"38","author":"Cahn","year":"2011","journal-title":"Eur Respir J"},{"key":"2024102021500572000_43.1.72.20","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00099306"},{"key":"2024102021500572000_43.1.72.21","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.1.47"},{"key":"2024102021500572000_43.1.72.22","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7245.1297"},{"key":"2024102021500572000_43.1.72.23","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2012.661492"},{"key":"2024102021500572000_43.1.72.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.11.009"},{"key":"2024102021500572000_43.1.72.25","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00238702"},{"key":"2024102021500572000_43.1.72.26","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00269802"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00033213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T01:45:15Z","timestamp":1740361515000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00033213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,15]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,12,31]]},"published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1183\/09031936.00033213"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00033213","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718078481.793532742","asserted-by":"object"}]},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,15]]}}}