{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:28:51Z","timestamp":1756312131981,"version":"3.37.3"},"reference-count":22,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2006,7,10]]},"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Respiratory involvement is a frequent complication of Stevens\u2013Johnson syndrome (SJS). However, there are very few convincing reports of persistent pulmonary sequelae, as demonstrated by spirometry, radiology and pathology.<\/jats:p><jats:p>The current study presents a case of a 13-yr-old female with T-cell acute lymphocytic leukaemia who developed persistent, severe, obstructive lung disease following an episode of SJS.<\/jats:p><jats:p>A lung biopsy demonstrated bronchiolar submucosal fibrosis consistent with constrictive bronchiolitis, as well as eosinophilic micro-abscesses, which, to the current authors\u2019 knowledge, has not been previously described.<\/jats:p><jats:p>The present study illustrates specific histopathological features that highlight a possible association between Stevens\u2013Johnson syndrome, constrictive bronchiolitis and eosinophilic micro-abscesses. The eosinophils may be associated with permanent mucosal damage, as seen in the present case, by releasing mediators that have a pro-fibrogenetic role. However, further investigation is warranted.<\/jats:p>","DOI":"10.1183\/09031936.00036006","type":"journal-article","created":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T16:53:05Z","timestamp":1164905585000},"page":"1276-1279","source":"Crossref","is-referenced-by-count":12,"title":["Severe airflow obstruction and eosinophilic lung disease after Stevens\u2013Johnson syndrome"],"prefix":"10.1183","volume":"28","author":[{"given":"A. P.","family":"Shah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Sime","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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