{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:32:04Z","timestamp":1793107924976,"version":"4.5.0"},"reference-count":36,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2010,6,17]]},"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>Patients with neuromuscular disease (NMD) are at risk of developing sleep-disordered breathing (SDB) following respiratory muscle involvement. We hypothesised that a questionnaire based on clinical symptoms and signs of diaphragm weakness can be used to screen for SDB in such patients.<\/jats:p><jats:p>We developed a self-administered multiple choice questionnaire containing five questions (Sleep-Disordered Breathing in Neuromuscular Disease Questionnaire (SiNQ)-5), scoring 0\u201310 points. 125 patients were enrolled: 32 with respiratory muscle weakness, 35 subjects with normal respiratory muscle strength and 58 patients with obstructive sleep apnoea (OSA). All subjects underwent full polysomnography.<\/jats:p><jats:p>NMD patients with involvement of the respiratory muscles scored mean\u00b1<jats:sc>sd<\/jats:sc>6.8\u00b12.3 out of 10 points, significantly higher than both OSA patients 2.5\u00b12.3 and normal subjects 1.0\u00b12.0 (p&lt;0.001). A score of five or more points in the SiNQ-5 had a sensitivity of 86.2%, specificity of 88.5%, positive predictive value of 69.4% and a negative predictive value of 95.5% to identify NMD with combined SDB.<\/jats:p><jats:p>A short self-administered questionnaire, the SiNQ-5, based on clinical symptoms can reliably screen for SDB in patients with diaphragm weakness. However, comorbidities, such as heart failure, that have symptoms influenced by posture could alter diagnostic accuracy.<\/jats:p>","DOI":"10.1183\/09031936.00036210","type":"journal-article","created":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T01:52:09Z","timestamp":1278035529000},"page":"400-405","source":"Crossref","is-referenced-by-count":42,"title":["Screening for sleep-disordered breathing in neuromuscular disease using a questionnaire for symptoms associated with diaphragm 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