{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T07:30:45Z","timestamp":1770017445035,"version":"3.49.0"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2010,8,17]]},"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>The emergence of new influenza virus subtypes has rekindled the interest in the clinical course and outcome of patients with influenza-associated pneumonia.<\/jats:p><jats:p>Based on prospective data from 5,032 patients with community-acquired pneumonia (CAP) included in the German Competence Network for Community-Acquired Pneumonia (CAPNETZ), we studied the incidence, clinical characteristics and outcome of patients with influenza-associated CAP and compared these findings with patients without influenza. Diagnosis relied on a positive PCR for influenza in throat washings.<\/jats:p><jats:p>160 patients with influenza-associated CAP were identified (3.2% of total population, 12% of those with defined aetiology). 34 (21%) patients with seasonal influenza had a concomitant pathogen (mostly<jats:italic>Streptococcus pneumoniae<\/jats:italic>). Patients with influenza-associated CAP were significantly older, had been vaccinated less often and had preceding antibacterial treatment less often. 30-day mortality was low (4.4%) and not different to that of patients with pneumonia caused by bacterial (6.2%) or viral (other than influenza) pathogens (4%). Patients with influenza plus a bacterial pathogen (mixed influenza-associated pneumonia) had a higher mortality than those with pure influenza-associated pneumonia (9%<jats:italic>versus<\/jats:italic>3.2%).<\/jats:p><jats:p>Mortality was higher in patients with mixed compared with pure influenza-associated pneumonia. However, we could not observe any excess mortality in patients with influenza-associated pneumonia.<\/jats:p>","DOI":"10.1183\/09031936.00037410","type":"journal-article","created":{"date-parts":[[2010,9,4]],"date-time":"2010-09-04T00:46:18Z","timestamp":1283561178000},"page":"1151-1157","source":"Crossref","is-referenced-by-count":53,"title":["How deadly is seasonal influenza-associated pneumonia? 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