{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:13:13Z","timestamp":1793293993665,"version":"4.5.0"},"reference-count":47,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,7,7]]},"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>Infection with HIV is the greatest risk factor for tuberculosis (TB) in Africa. Tuberculin skin test (TST), QuantiFERON-TB Gold In-Tube (QFT-G-IT) and T-Spot.TB assays were performed in newly diagnosed HIV-infected individuals with and without active TB and in HIV-uninfected subjects at a university outpatient clinic in Kampala, Uganda.<\/jats:p><jats:p>A total of 135 individuals were enrolled: 109 with a new diagnosis of HIV-1 infection but no active TB, 19 with HIV-1 infection and active TB, and seven HIV-uninfected healthy subjects. In control subjects immune responses were positive in 57.2% by TST and in 100% by at least one interferon-\u03b3 release assay.<\/jats:p><jats:p>In HIV-1 infected patients without active TB, induration in the TST (mm) (rho\u200a=\u200a0.41, p-value &lt;0.0001) and concentration of interferon (IFN)-\u03b3 in the QFT-G-IT tube with<jats:italic>Mycobacterium tuberculosis<\/jats:italic>-specific antigens (rho\u200a=\u200a0.38; p\u200a=\u200a0.0001) were negatively correlated to numbers of circulating CD4+ T-cells, while numbers of IFN-\u03b3 producing cells (rho\u200a=\u200a0.03\u20130.13; p-value\u200a=\u200a0.21\u20130.77) and frequencies of positive test results for the T-Spot.TB test among groups of patients with different levels of immunodeficiency remained constant (p-value\u200a=\u200a0.46).<\/jats:p><jats:p>In HIV-1 infection, TST and QFT-G-IT immune responses are both strongly related to the degree of immunodeficiency, while results of the T-Spot.TB are independent of the level of CD4+ T-cell depletion.<\/jats:p>","DOI":"10.1183\/09031936.00045509","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T00:26:05Z","timestamp":1247790365000},"page":"619-626","source":"Crossref","is-referenced-by-count":75,"title":["Relationship of immunodiagnostic assays for tuberculosis and numbers of circulating CD4+ T-cells in HIV infection"],"prefix":"10.1183","volume":"35","author":[{"given":"L.","family":"Leidl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mayanja-Kizza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sotgiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Baseke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Goletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Toossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2009,7,16]]},"reference":[{"key":"2024102019593298000_35.3.619.1","unstructured":"World Health Organization. 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