{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:00:13Z","timestamp":1792116013164,"version":"4.4.0"},"reference-count":40,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,10,7]]},"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>Aerobic training (AT) decreases dyspnoea and exercise-induced bronchospasm, and improves aerobic capacity and quality of life; however, the mechanisms for such benefits remain poorly understood. The aim of the present study was to evaluate the AT effects in a chronic model of allergic lung inflammation in mice after the establishment of airway inflammation and remodelling.<\/jats:p><jats:p>Mice were divided into the control group, AT group, ovalbumin (OVA) group or OVA+AT group and exposed to saline or OVA. AT was started on day 28 for 60\u2005min five times per week for 4\u2005weeks. Respiratory mechanics, specific immunoglobulin (Ig)E and IgG<jats:sub>1<\/jats:sub>, collagen and elastic fibres deposition, smooth muscle thickness, epithelial mucus, and peribronchial density of eosinophils, CD3+ and CD4+, IL-4, IL-5, IL-13, interferon-\u03b3, IL-2, IL-1ra, IL-10, nuclear factor (NF)-\u03baB and Foxp3 were evaluated.<\/jats:p><jats:p>The OVA group showed an increase in IgE and IgG<jats:sub>1<\/jats:sub>, eosinophils, CD3+, CD4+, IL-4, IL-5, IL-13, NF-\u03baB, collagen and elastic, mucus synthesis, smooth muscle thickness and lung tissue resistance and elastance. The OVA+AT group demonstrated an increase of IgE and IgG<jats:sub>1<\/jats:sub>, and reduction of eosinophils, CD3+, CD4+, IL-4, IL-5, IL-13, NF-\u03baB, airway remodelling, mucus synthesis, smooth muscle thickness and tissue resistance and elastance compared with the OVA group (p&lt;0.05). The OVA+AT group also showed an increase in IL-10 and IL-1ra (p&lt;0.05), independently of Foxp3.<\/jats:p><jats:p>AT reversed airway inflammation and remodelling and T-helper cell 2 response, and improved respiratory mechanics. These results seem to occur due to an increase in the expression of IL-10 and IL-1ra and a decrease of NF-\u03baB.<\/jats:p>","DOI":"10.1183\/09031936.00049509","type":"journal-article","created":{"date-parts":[[2009,11,7]],"date-time":"2009-11-07T02:18:23Z","timestamp":1257560303000},"page":"994-1002","source":"Crossref","is-referenced-by-count":72,"title":["Aerobic training reverses airway inflammation and remodelling in an asthma murine model"],"prefix":"10.1183","volume":"35","author":[{"given":"R. A.","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. P.","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C. 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