{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:15:45Z","timestamp":1777526145969,"version":"3.51.4"},"reference-count":37,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2010,9,7]]},"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>The objective of this study was to determine whether genetic polymorphisms in enzymes that metabolise oxidative agents modify the individual susceptibility to developing asbestos and smoking-related pleuropulmonary changes.<\/jats:p><jats:p>Nine polymorphisms of six genes (<jats:italic>EPHX1<\/jats:italic>,<jats:italic>GSTM1<\/jats:italic>,<jats:italic>GSTM3<\/jats:italic>,<jats:italic>GSTP1, GSTT1<\/jats:italic>and<jats:italic>NAT2<\/jats:italic>) were genotyped from 1,008 Finnish asbestos-exposed workers. The genotype data were compared to signs of lung fibrosis and pleural thickenings, as well as with total lung capacity, single-breath diffusing capacity of the lung for carbon monoxide (<jats:italic>D<\/jats:italic><jats:sub>L,CO<\/jats:sub>) and specific diffusing capacity (expressed as<jats:italic>D<\/jats:italic><jats:sub>L,CO<\/jats:sub>per unit of alveolar volume (<jats:italic>V<\/jats:italic><jats:sub>A<\/jats:sub>)).<\/jats:p><jats:p>The<jats:italic>GSTT1<\/jats:italic>deletion polymorphism was associated with fibrotic changes (p=0.003), and decreased<jats:italic>D<\/jats:italic><jats:sub>L,CO<\/jats:sub>(p=0.02) and<jats:italic>D<\/jats:italic><jats:sub>L,CO<\/jats:sub>\/<jats:italic>V<\/jats:italic><jats:sub>A<\/jats:sub>(p=0.002), and the<jats:italic>GSTM1<\/jats:italic>deletion polymorphism was associated with the greatest thickness of pleural plaques (p=0.009). On further analysis, the<jats:italic>GSTT1<\/jats:italic>null genotype was found to pose over a three-fold risk for severe fibrotic changes (OR 3.12, 95% CI 1.51\u20136.43), and around two-fold risks for decreased<jats:italic>D<\/jats:italic><jats:sub>L,CO<\/jats:sub>(OR 1.77, 95% CI 1.06\u20132.95) and<jats:italic>D<\/jats:italic><jats:sub>L,CO<\/jats:sub>\/<jats:italic>V<\/jats:italic><jats:sub>A<\/jats:sub>(OR 2.37, 95% CI 1.33\u20134.23). In addition, the<jats:italic>GSTM1<\/jats:italic>null genotype showed an elevated risk (OR 1.36, 95% CI 1.03\u20131.80) for thicker pleural plaques.<\/jats:p><jats:p>Our data suggest that inherited detoxification capacity may affect the development and severity of asbestos and smoking-related nonmalignant pulmonary changes.<\/jats:p>","DOI":"10.1183\/09031936.00049810","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T01:09:59Z","timestamp":1284685799000},"page":"672-678","source":"Crossref","is-referenced-by-count":13,"title":["Genetic susceptibility to asbestos-related fibrotic pleuropulmonary 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