{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:12:36Z","timestamp":1790010756466,"version":"4.0.1"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2013,6,28]]},"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Pneumococcal serotypes are one of the main determinants of pneumococcal disease severity; however, data about their implication in respiratory failure are scarce.<\/jats:p>\n                  <jats:p>We conducted an observational study of adults hospitalised with invasive pneumococcal pneumonia to describe the host- and pathogen-related factors associated with respiratory failure.<\/jats:p>\n                  <jats:p>\n                    Of 1258 adults with invasive pneumococcal disease, 615 (48.9%) had respiratory failure at presentation. Patients with respiratory failure were older (62.1 years\n                    <jats:italic>versus<\/jats:italic>\n                    55.4 years, p&lt;0.001) and had a greater proportion of comorbid conditions. They also had a greater proportion of septic shock (41.7%\n                    <jats:italic>versus<\/jats:italic>\n                    6.1%, p&lt;0.001), required admission to the intensive care unit more often (38.4%\n                    <jats:italic>versus<\/jats:italic>\n                    4.2%, p&lt;0.001) and had a higher mortality (25.5%\n                    <jats:italic>versus<\/jats:italic>\n                    3.5%, p&lt;0.001). After adjustment, independent risk factors for respiratory failure were: age &gt;50 years (OR 1.63, 95% CI 1.15\u20132.3), chronic lung disease (OR 1.54, 95% CI 1.1\u20132.15), chronic heart disease (OR 1.49, 95% CI 1.01\u20132.22) and infection caused by serotypes 3 (OR 1.97, 95% CI 1.23\u20133.16), 19A (OR 2.34, 95% CI 1.14\u20134.42) and 19F (OR 3.55, 95% CI 1.22\u201310.28).\n                  <\/jats:p>\n                  <jats:p>In conclusion, respiratory failure is a frequent complication of pneumococcal pneumonia and causes high morbidity and mortality. Pneumococcal serotypes 3, 19A and 19F are the main risk factors for this complication.<\/jats:p>","DOI":"10.1183\/09031936.00050413","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T22:55:46Z","timestamp":1373583346000},"page":"545-553","source":"Crossref","is-referenced-by-count":44,"title":["Risk factors for respiratory failure in pneumococcal pneumonia: the importance of pneumococcal serotypes"],"prefix":"10.1183","volume":"43","author":[{"given":"Joaqu\u00edn","family":"Burgos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Luj\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Nieves","family":"Larrosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dion\u00edsia","family":"Fontanals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Bermudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Planes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Puig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Rello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicen\u00e7","family":"Falc\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Pahissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2013,7,11]]},"reference":[{"key":"2026092109352630000_43.2.545.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03190.x"},{"key":"2026092109352630000_43.2.545.2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1986.00360230105016"},{"key":"2026092109352630000_43.2.545.3","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.4.801"},{"key":"2026092109352630000_43.2.545.4","doi-asserted-by":"publisher","DOI":"10.1086\/518538"},{"key":"2026092109352630000_43.2.545.5","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/142.2.175"},{"key":"2026092109352630000_43.2.545.6","doi-asserted-by":"publisher","DOI":"10.1086\/514005"},{"key":"2026092109352630000_43.2.545.7","doi-asserted-by":"publisher","DOI":"10.1086\/423820"},{"key":"2026092109352630000_43.2.545.8","doi-asserted-by":"publisher","DOI":"10.1086\/499242"},{"key":"2026092109352630000_43.2.545.9","doi-asserted-by":"publisher","DOI":"10.1086\/600045"},{"key":"2026092109352630000_43.2.545.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03895.x"},{"key":"2026092109352630000_43.2.545.11","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.123612"},{"key":"2026092109352630000_43.2.545.12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0018OC"},{"key":"2026092109352630000_43.2.545.13","unstructured":"PIDIRAC. 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