{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:37:29Z","timestamp":1792107449370,"version":"4.4.0"},"reference-count":25,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2007,5,16]]},"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>Melatonin is a pineal hormone that regulates the human cycle of sleep and wakefulness. Plasma melatonin levels were investigated in patients with obstructive sleep apnoea syndrome (OSAS).<\/jats:p>\n                  <jats:p>In total, 20 patients with OSAS and 11 healthy controls were studied. OSAS patients were tested twice: on the night of diagnostic polysomnography and the night of continuous positive airway pressure (CPAP) titration. Controls were tested on one occasion. Plasma melatonin levels were determined at 23:00\u2005h (light period), at 02:00\u2005h (dark period) and at 06:00\u2005h (light period) in patients and control subjects using the radioimmunoassay method.<\/jats:p>\n                  <jats:p>\n                    The control subjects showed a nocturnal melatonin peak value at 02:00\u2005h (70.6\u00b114\u2005pg\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). However, this nocturnal melatonin peak was absent in the OSAS patients. The highest melatonin value was found in OSAS patients on the night of diagnosis, at 06:00\u2005h (49.3\u00b136.8\u2005pg\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). It was found that the melatonin level in OSAS patients at 06:00\u2005h was significantly lower in the night of titration (35.6\u00b137.9\u2005pg\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) than in the diagnosis night. However, the melatonin levels at either 23:00\u2005h or 02:00\u2005h in OSAS patients did not differ significantly when comparing levels in the night of diagnostic polysomnography (23:00\u2005h: 31.6\u00b129.8\u2005pg\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ; 02:00\u2005h: 47.4\u00b133.8\u2005pg\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) with levels in the night of CPAP titration (23:00\u2005h: 20.2\u00b110.3\u2005pg\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ; 02:00\u2005h: 37.7\u00b127.5\u2005pg\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ).\n                  <\/jats:p>\n                  <jats:p>Patients with obstructive sleep apnoea syndrome have an abnormal melatonin secretion pattern. The absence of a nocturnal serum melatonin peak could be partially related to the difficulty that these patients have in achieving a normal sleep\u2013wakefulness pattern.<\/jats:p>","DOI":"10.1183\/09031936.00051906","type":"journal-article","created":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T20:19:24Z","timestamp":1180556364000},"page":"496-500","source":"Crossref","is-referenced-by-count":57,"title":["Nocturnal melatonin plasma levels in patients with OSAS: the effect of CPAP"],"prefix":"10.1183","volume":"30","author":[{"given":"C.","family":"Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Abreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Abreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2007,5,30]]},"reference":[{"key":"2024102019190398000_30.3.496.1","first-page":"289","volume":"13","year":"1978","journal-title":"J Neural Transm Suppl"},{"key":"2024102019190398000_30.3.496.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-002-0579-y"},{"key":"2024102019190398000_30.3.496.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.7434030"},{"key":"2024102019190398000_30.3.496.4","first-page":"841","volume":"10","year":"1971","journal-title":"Life Sci I"},{"key":"2024102019190398000_30.3.496.5","doi-asserted-by":"crossref","first-page":"R1178","DOI":"10.1152\/ajpcell.1997.272.4.C1178","volume":"272","year":"1997","journal-title":"Am J Physiol"},{"key":"2024102019190398000_30.3.496.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00695.x"},{"key":"2024102019190398000_30.3.496.7","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-60-6-1166"},{"key":"2024102019190398000_30.3.496.8","doi-asserted-by":"publisher","DOI":"10.1080\/07420520500545854"},{"key":"2024102019190398000_30.3.496.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00051504"},{"key":"2024102019190398000_30.3.496.10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00306502"},{"key":"2024102019190398000_30.3.496.11","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00216902"},{"key":"2024102019190398000_30.3.496.12","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1093\/sleep\/20.11.1002","volume":"20","year":"1997","journal-title":"Sleep"},{"key":"2024102019190398000_30.3.496.13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1998.00359.x"},{"key":"2024102019190398000_30.3.496.14","first-page":"650","volume":"69","year":"2001","journal-title":"Pneumonol Alergol Pol"},{"key":"2024102019190398000_30.3.496.15","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-12-2-151"},{"key":"2024102019190398000_30.3.496.16","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00106402"},{"key":"2024102019190398000_30.3.496.17","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00015604"},{"key":"2024102019190398000_30.3.496.18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0300-2896(15)30454-3","volume":"34","year":"1998","journal-title":"Arch Bronconeumol"},{"key":"2024102019190398000_30.3.496.19","unstructured":"Rechtschaffen A, Kales AA. eds. 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