{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:48:34Z","timestamp":1774126114680,"version":"3.50.1"},"reference-count":24,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2007,10,12]]},"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p>In the present study, T-Spot.TB and the tuberculin skin test (TST) were compared in the screening of latent tuberculosis infection among silicotic patients.<\/jats:p><jats:p>A conditional probability model was used to compare the potential clinical utilities of T-Spot.TB and TST performed on 134 silicotic subjects from December 1, 2004 to January 31, 2007. Data from a historical cohort were also reanalysed for further comparison.<\/jats:p><jats:p>Agreement with T-Spot.TB was best using a TST cut-off of 10\u2005mm. Age \u226565\u2005yrs independently predicted a tuberculin reaction &lt;10\u2005mm (odds ratio\u200a=\u200a3), but not a negative T-Spot.TB response. Lower measures of agreement were observed among current smokers and those aged \u226565\u2005yrs. Tuberculin reaction size was well correlated with both early secretary antigenic target 6 and culture filtrate protein 10 spot counts, except among current smokers. Within the current estimates of sensitivity (88\u201395%) and specificity (86\u201399%) for T-Spot.TB, the positive likelihood ratio for T-Spot.TB test would be substantially higher (6.29\u201395.0<jats:italic>versus<\/jats:italic>1.65\u20131.94) and negative likelihood ratio substantially lower (0.05\u20130.14<jats:italic>versus<\/jats:italic>0.32\u20130.41) than the corresponding ratios for the tuberculin test. A low tuberculosis risk differential was similarly observed between tuberculin-negative and untreated tuberculin-positive subjects in the historical cohort.<\/jats:p><jats:p>T-Spot.TB is likely to perform better than tuberculin test in the screening of latent tuberculosis infection among silicotic subjects.<\/jats:p>","DOI":"10.1183\/09031936.00054707","type":"journal-article","created":{"date-parts":[[2007,10,24]],"date-time":"2007-10-24T22:51:55Z","timestamp":1193266315000},"page":"266-272","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of T-Spot.TB and tuberculin skin test among silicotic patients"],"prefix":"10.1183","volume":"31","author":[{"given":"C. C.","family":"Leung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. C.","family":"Yam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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