{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:13:45Z","timestamp":1790331225980,"version":"4.1.0"},"reference-count":44,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,8,24]]},"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>The aim of the present study was to examine whether prone positioning (PP) affects ventilator associated-pneumonia (VAP) and mortality in patients with acute lung injury\/adult respiratory distress syndrome.<\/jats:p><jats:p>2,409 prospectively included patients were admitted over 9 yrs (2000\u20132008) to 12 French intensive care units (ICUs) (OUTCOMEREA). The patients required invasive mechanical ventilation (MV) and had arterial oxygen tension\/inspiratory oxygen fraction ratios &lt;300 during the first 48 h. Controls were matched to PP patients on the PP propensity score (\u00b110%), MV duration longer than that in PP patients before the first turn prone, and centre.<\/jats:p><jats:p>VAP incidence was similar in the PP and control groups (24<jats:italic>versus<\/jats:italic>13 episodes\u00b71,000 patient-days MV<jats:sup>\u22121<\/jats:sup>respectively, p\u200a=\u200a0.14). After adjustment, PP did not decrease VAP occurrence (HR 1.64 (95% CI 0.70\u20133.84); p\u200a=\u200a0.25) but significantly delayed hospital mortality (HR 0.56 (95% CI 0.39\u20130.79); p\u200a=\u200a0.001), without decreasing 28-day mortality (37% in both groups).<jats:italic>Post hoc<\/jats:italic>analyses indicated that PP did not protect against VAP but, when used for &gt;1 day, might decrease mortality and benefit the sickest patients (Simplified Acute Physiology Score &gt;50).<\/jats:p><jats:p>In ICU patients with hypoxaemic acute respiratory failure, PP had no effect on the risk of VAP. PP delayed mortality without decreasing 28-day mortality. PP &gt;1 day might decrease mortality, particularly in the sickest patients.<\/jats:p>","DOI":"10.1183\/09031936.00057509","type":"journal-article","created":{"date-parts":[[2009,9,10]],"date-time":"2009-09-10T00:56:09Z","timestamp":1252544169000},"page":"795-804","source":"Crossref","is-referenced-by-count":20,"title":["Study of prone positioning to reduce ventilator-associated pneumonia in hypoxaemic patients"],"prefix":"10.1183","volume":"35","author":[{"given":"R.","family":"Mounier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Adrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fran\u00e7ais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Garrouste-Orgeas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cheval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Allaouchiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jamali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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