{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:13:12Z","timestamp":1791216792904,"version":"4.1.0"},"reference-count":56,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,1,12]]},"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>\n                    Airway remodelling, characterised by increased airway smooth muscle (ASM) mass, subepithelial fibrosis, goblet cell hyperplasia and mucus gland hypertrophy, is a feature of chronic asthma. Increased arginase activity could contribute to these features\n                    <jats:italic>via<\/jats:italic>\n                    increased formation of polyamines and\n                    <jats:sc>l<\/jats:sc>\n                    -proline downstream of the arginase product\n                    <jats:sc>l<\/jats:sc>\n                    -ornithine, and\n                    <jats:italic>via<\/jats:italic>\n                    reduced nitric oxide synthesis.\n                  <\/jats:p>\n                  <jats:p>\n                    Using the specific arginase inhitibor 2(S)-amino-6-boronohexanoic acid (ABH), we studied the role of arginase in airway remodelling using a guinea pig model of chronic asthma. Ovalbumin-sensitised guinea pigs were treated with ABH or PBS\n                    <jats:italic>via<\/jats:italic>\n                    inhalation before each of 12 weekly allergen or saline challenges, and indices of arginase activity, and airway remodelling, inflammation and responsiveness were studied 24 h after the final challenge.\n                  <\/jats:p>\n                  <jats:p>\n                    Pulmonary arginase activity of repeatedly allergen-challenged guinea pigs was increased. Allergen challenge also increased ASM mass and maximal contraction of denuded tracheal rings, which were prevented by ABH. ABH also attenuated allergen-induced pulmonary hydroxyproline (fibrosis) and putrescine, mucus gland hypertrophy, goblet cell hyperplasia, airway eosinophilia and interleukin-13, whereas an increased\n                    <jats:sc>l<\/jats:sc>\n                    -ornithine\/\n                    <jats:sc>l<\/jats:sc>\n                    -citrulline ratio in the lung was normalised. Moreover, allergen-induced hyperresponsiveness of perfused tracheae was fully abrogated by ABH.\n                  <\/jats:p>\n                  <jats:p>These findings demonstrate that arginase is prominently involved in allergen-induced airway remodelling, inflammation and hyperresponsiveness in chronic asthma.<\/jats:p>","DOI":"10.1183\/09031936.00057710","type":"journal-article","created":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T22:53:01Z","timestamp":1297378381000},"page":"318-328","source":"Crossref","is-referenced-by-count":92,"title":["Increased arginase activity contributes to airway remodelling in chronic allergic 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