{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:22:20Z","timestamp":1790767340967,"version":"4.1.0"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":["ersjournals.com"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2014,8,4]]},"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Isolated cases of pulmonary arterial hypertension (PAH) in patients treated with interferon (IFN) \u03b1 or \u03b2 have been reported in the literature.<\/jats:p><jats:p>The aim of this study was to describe all consecutive cases of PAH patients with a history of IFN exposure identified in the French reference centre for severe pulmonary hypertension between 1998 and 2012.<\/jats:p><jats:p>A total of 53 patients with PAH and a history of IFN therapy were identified. 48 patients had been treated with IFN\u03b1 for chronic hepatitis C. Most of them had portal hypertension (85%) and 56% had HIV co-infection. Five additional patients had been treated with IFN\u03b2 for multiple sclerosis. The diagnosis of PAH was made within 3 years after IFN therapy in 66% of patients. Repeated haemodynamic assessment was available in 13 out of 16 patients exposed to IFN after the diagnosis of PAH. Increased pulmonary vascular resistance &gt;20% was observed in 11 out of 13 cases (median 43% increase; IQR 32\u201367%). In five of these patients, IFN withdrawal resulted in spontaneous haemodynamic improvement.<\/jats:p><jats:p>This retrospective analysis suggests that IFN therapy may trigger PAH. However, most of these patients had other risk factors for PAH. A prospective case\u2013control study is necessary to definitively establish a link between IFN exposure and PAH.<\/jats:p>","DOI":"10.1183\/09031936.00057914","type":"journal-article","created":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T10:08:52Z","timestamp":1413540532000},"page":"1627-1634","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":95,"title":["Pulmonary arterial hypertension in patients treated with 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