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Male C57BL\/6 mice were subjected to cigarette smoke exposure for up to 3 months followed by a 28-day cessation period. We quantified bronchiolar catalase mRNA using laser capture microdissection and quantitative reverse transcription-polymerase chain reaction. C22 club cells (Clara cells) in culture were exposed to cigarette smoke extract and monitored for viability when catalase expression was decreased by siRNA.<\/jats:p><jats:p>Catalase was decreased at mRNA and protein levels in bronchiolar epithelium in smokers with COPD. In mice, bronchiolar catalase is temporarily upregulated at 1 day after cigarette smoke exposure but is downregulated by repeated cigarette smoke exposure, and is not restored long after withdrawal once emphysema is developed. Decreasing catalase expression in C22 cells resulted in greater cigarette smoke extract-induced cell death.<\/jats:p><jats:p>Bronchiolar catalase reduction is associated with COPD. Regulation of catalase depends on the duration of cigarette smoke exposure, and plays a critical role for protection against cigarette smoke-induced cell damage.<\/jats:p>","DOI":"10.1183\/09031936.00058912","type":"journal-article","created":{"date-parts":[[2012,10,26]],"date-time":"2012-10-26T07:21:12Z","timestamp":1351236072000},"page":"42-53","source":"Crossref","is-referenced-by-count":25,"title":["Bronchiolar epithelial catalase is diminished in smokers with mild COPD"],"prefix":"10.1183","volume":"42","author":[{"given":"Tomoko","family":"Betsuyaku","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Fuke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Inomata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kichizo","family":"Kaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Odajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Adair-Kirk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2012,10,25]]},"reference":[{"key":"2024102021225966000_42.1.42.1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200905-027DS"},{"key":"2024102021225966000_42.1.42.2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200421146"},{"key":"2024102021225966000_42.1.42.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032158"},{"key":"2024102021225966000_42.1.42.4","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0295OC"},{"key":"2024102021225966000_42.1.42.5","doi-asserted-by":"crossref","unstructured":"Betsuyaku T Hamamura I Hata J . 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