{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:45:20Z","timestamp":1791078320684,"version":"4.1.0"},"reference-count":19,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,8,17]]},"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>Biomarkers providing<jats:italic>in vivo<\/jats:italic>quantification of the basic elements of cystic fibrosis (CF) lung disease are needed. A study was performed to determine whether the absorption of a small radiolabelled hydrophilic molecule (Indium-111 (In-)DTPA) would be increased in CF airways. DTPA clearance has been used previously to assess epithelial permeability and may also be useful for quantifying liquid absorption.<\/jats:p><jats:p>The absorptive clearance rate of DTPA was quantified in 10 CF and 11 control subjects using a novel aerosol technique. Subjects inhaled an aerosol containing nonabsorbable technetium-99m sulfur colloid (Tc-SC) particles and In-DTPA. Tc-SC clearance from the lung is exclusively mucociliary, while In-DTPA is cleared by both absorption and mucociliary clearance. The difference between the In-DTPA and Tc-SC clearance rates estimates In-DTPA absorption.<\/jats:p><jats:p>Tc-SC (mucociliary) clearance was similar in central and peripheral zones in CF and non-CF lungs. Total In-DTPA clearance was increased in both zones in CF lungs. The absorptive component of In-DTPA clearance was increased in the airway-dominated central lung zones in CF (42%\u00b7h<jats:sup>\u22121<\/jats:sup><jats:italic>versus<\/jats:italic>32%\u00b7h<jats:sup>\u22121<\/jats:sup>, p\u200a=\u200a0.03).<\/jats:p><jats:p>The absorption of In-DTPA is increased in the CF airway. Further study is needed to understand the relative roles of fluid absorption, inflammation and other mechanisms potentially affecting epithelial permeability and DTPA absorption.<\/jats:p>","DOI":"10.1183\/09031936.00059009","type":"journal-article","created":{"date-parts":[[2009,8,29]],"date-time":"2009-08-29T00:25:44Z","timestamp":1251505544000},"page":"781-786","source":"Crossref","is-referenced-by-count":19,"title":["Absorptive clearance of DTPA as an aerosol-based biomarker in the cystic fibrosis airway"],"prefix":"10.1183","volume":"35","author":[{"given":"T. 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