{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:40:02Z","timestamp":1790016002167,"version":"4.0.1"},"reference-count":33,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":["ersjournals.com"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2014,6,29]]},"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Reliable methods are needed to diagnose hypersensitivity pneumonitis. The aim of the study was to establish the diagnostic yield of specific inhalation challenge (SIC) in patients with hypersensitivity pneumonitis.<\/jats:p>\n                  <jats:p>All patients with suspected hypersensitivity pneumonitis in whom SIC was performed (n=113) were included. SIC was considered positive when patients showed a decrease of &gt;15% in forced vital capacity (FVC) or &gt;20% in diffusing capacity of the lung for carbon dioxide, or a decrease of 10% to 15% in FVC accompanied by a temperature increase of 0.5\u00b0C within 24 h of inhalation of the antigen.<\/jats:p>\n                  <jats:p>SIC was positive to the agents tested in 68 patients: 64 received a diagnosis of hypersensitivity pneumonitis and SIC results were considered false-positive in the remaining four patients. In the SIC-negative group (n=45), 24 patients received a diagnosis of hypersensitivity pneumonitis and SIC results were considered false-negative, and 21 patients were diagnosed with other respiratory diseases. The sensitivity and specificity of the test were 72.7% and 84%, respectively. Having hypersensitivity pneumonitis caused by an antigen other than birds or fungi predicted a false-negative result (p=0.001).<\/jats:p>\n                  <jats:p>In hypersensitivity pneumonitis, positive SIC testing virtually confirms the diagnosis, whereas negative testing does not rule it out, especially when the antigenic sources are not birds or fungi.<\/jats:p>","DOI":"10.1183\/09031936.00060714","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T00:06:57Z","timestamp":1408579617000},"page":"1658-1665","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":76,"title":["Diagnostic yield of specific inhalation challenge in hypersensitivity pneumonitis"],"prefix":"10.1183","volume":"44","author":[{"given":"Xavier","family":"Mu\u00f1oz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"S\u00e1nchez-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Villar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Morell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Jes\u00fas","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2014,8,19]]},"reference":[{"key":"2024102022594468000_44.6.1658.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2004.04.001"},{"key":"2024102022594468000_44.6.1658.2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.3.534"},{"key":"2024102022594468000_44.6.1658.3","unstructured":"Selman M . 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