{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:48:39Z","timestamp":1793148519076,"version":"4.5.0"},"reference-count":28,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,8,10]]},"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>Circulating cardiac troponins are markers of myocardial injury. We sought to determine whether cardiac troponin I (cTnI), measured by a sensitive assay, is associated with disease severity and prognosis in pulmonary arterial hypertension (PAH).<\/jats:p>\n                  <jats:p>\n                    cTnI was measured in 68 patients with PAH diagnostic category 1 in a research-based sensitive immunoanalyser with a lower limit of detection of 0.008 ng\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    . The associations between cTnI and PAH severity and clinical outcomes were assessed using Chi-squared and Wilcoxon rank sum tests, Kaplan\u2013Meier analysis and Cox regression models.\n                  <\/jats:p>\n                  <jats:p>\n                    cTnI was detected in 25% of patients. Patients with detectable cTnI had more advanced functional class symptoms, a shorter 6-min walk distance, more pericardial effusions, larger right atrial area, and higher B-type natriuretic peptide and C-reactive protein levels. 36-month transplant-free survival was 44% in patients with detectable cTnI\n                    <jats:italic>versus<\/jats:italic>\n                    85% in those with undetectable cTnI. cTnI was associated with a 4.7-fold increased risk of death related to right ventricular failure or transplant (hazard ratio 4.74, 95% CI 1.89\u201311.89; p&lt;0.001), even when adjusted individually for known parameters of PAH severity.\n                  <\/jats:p>\n                  <jats:p>Elevated plasma cTnI, even at subclinically detectable levels, is associated with more severe disease and worse outcomes in patients with PAH.<\/jats:p>","DOI":"10.1183\/09031936.00067011","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T20:59:55Z","timestamp":1314910795000},"page":"939-944","source":"Crossref","is-referenced-by-count":61,"title":["Sensitive cardiac troponin I predicts poor outcomes in pulmonary arterial hypertension"],"prefix":"10.1183","volume":"39","author":[{"given":"G.A.","family":"Heresi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.H.W.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Aytekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hammel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.L.","family":"Hazen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.","family":"Dweik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2011,9,1]]},"reference":[{"key":"2024102020490429000_39.4.939.1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0492"},{"key":"2024102020490429000_39.4.939.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00057010"},{"key":"2024102020490429000_39.4.939.3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2674"},{"key":"2024102020490429000_39.4.939.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00160307"},{"key":"2024102020490429000_39.4.939.5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.182882"},{"key":"2024102020490429000_39.4.939.6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.708529"},{"key":"2024102020490429000_39.4.939.7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000084543.79097.34"},{"key":"2024102020490429000_39.4.939.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000041254.30637.34"},{"key":"2024102020490429000_39.4.939.9","doi-asserted-by":"publisher","DOI":"10.1007\/s001340100920"},{"key":"2024102020490429000_39.4.939.10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.4.2758"},{"key":"2024102020490429000_39.4.939.11","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00033109"},{"key":"2024102020490429000_39.4.939.12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000084544.54513.E2"},{"key":"2024102020490429000_39.4.939.13","doi-asserted-by":"publisher","DOI":"10.1042\/CS20100014"},{"key":"2024102020490429000_39.4.939.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.012"},{"key":"2024102020490429000_39.4.939.15","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.201210"},{"key":"2024102020490429000_39.4.939.16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900428"},{"key":"2024102020490429000_39.4.939.17","unstructured":"R Development Core Team. 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R Foundation for Statistical Computing V, Austria, 2008. www.R-project.org Date last accessed: November 21, 2011."},{"key":"2024102020490429000_39.4.939.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.038"},{"key":"2024102020490429000_39.4.939.19","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0007OC"},{"key":"2024102020490429000_39.4.939.20","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp297"},{"key":"2024102020490429000_39.4.939.21","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.5.1313"},{"key":"2024102020490429000_39.4.939.22","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00100407"},{"key":"2024102020490429000_39.4.939.23","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00070209"},{"key":"2024102020490429000_39.4.939.24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1742-1241.2010.02598.x","article-title":"Clinical perspective: biomarkers in pulmonary arterial hypertension","volume":"169","author":"Heresi","year":"2011","journal-title":"Int J Clin Pract Suppl"},{"key":"2024102020490429000_39.4.939.25","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0608"},{"key":"2024102020490429000_39.4.939.26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903515"},{"key":"2024102020490429000_39.4.939.27","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1768"},{"key":"2024102020490429000_39.4.939.28","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1708"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00067011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T01:32:26Z","timestamp":1740360746000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00067011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,1]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,3,31]]},"published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1183\/09031936.00067011"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00067011","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.14264014.15777127","asserted-by":"object"}]},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,1]]}}}