{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T18:00:31Z","timestamp":1769277631465,"version":"3.49.0"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,10,1]]},"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Bronchoscopic lung volume reduction (BLVR) is a novel emphysema therapy. We evaluated long-term outcome in patients with heterogeneous emphysema undergoing BLVR with one-way valves.<\/jats:p><jats:p>40 patients undergoing unilateral BLVR entered our study. Pre-operative mean forced expiratory volume in 1 s (FEV<jats:sub>1<\/jats:sub>) was 0.88 L\u00b7s<jats:sup>\u22121<\/jats:sup>(23%), total lung capacity was 7.45 L (121%), intrathoracic gas volume was 6 L (174%), residual volume (RV) was 5.2 L (232%), and the 6-min walk test (6MWT) was 286 m. All patients required supplemental oxygen; the Medical Research Council (MRC) dyspnoea score was 3.9. High-resolution computed tomography (HRCT) results were reviewed to assess the presence of interlobar fissures.<\/jats:p><jats:p>33 patients had a follow-up of &gt;12 months (median 32 months). 37.5% of the patients had visible interlobar fissures. 40% of the patients died during follow-up. Three patients were transplanted and one underwent lung volume reduction surgery. Supplemental oxygen, FEV<jats:sub>1<\/jats:sub>, RV, 6MWT and MRC score showed a statistically significant improvement (p\u22640.0001, p=0.004, p=0.03, p=0.003 and p&lt;0.0001, respectively). Patients with visible fissures had a functional advantage.<\/jats:p><jats:p>BLVR is feasible and safe. Long-term sustained improvements can be achieved. HRCT-visible interlobar fissures are a favourable prognostic factor.<\/jats:p>","DOI":"10.1183\/09031936.00071311","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T04:27:52Z","timestamp":1318912072000},"page":"1084-1089","source":"Crossref","is-referenced-by-count":67,"title":["Long-term follow-up after bronchoscopic lung volume reduction in patients with emphysema"],"prefix":"10.1183","volume":"39","author":[{"given":"Federico","family":"Venuta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Anile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Diso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Carillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziano","family":"De 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