{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:02:46Z","timestamp":1791180166021,"version":"4.1.0"},"reference-count":28,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,2,8]]},"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>Atrial septostomy (AS) is a palliative treatment for right ventricular failure from severe pulmonary arterial hypertension (PAH). We sought to investigate the effect of AS, alone or combined with PAH-specific pharmacotherapy, on the survival of patients with PAH.<\/jats:p><jats:p>We performed a retrospective analysis of the functional and haemodynamic changes in patients with PAH following AS, and long-term survival characteristics for the whole group and separately for the subgroup who received post-procedural pharmacotherapy.<\/jats:p><jats:p>50 procedures performed in 34 patients (mean\u00b1<jats:sc>sd<\/jats:sc>age 35\u00b110 yrs) resulted in haemodynamic and symptomatic improvement in most of the patients. Only one (2%) procedure-related death occurred. Due to spontaneous closure of the defect, AS was repeated in 10 patients. In 21 patients, AS was the only form of treatment, while 11 received additional pharmacotherapy after AS. During follow-up (58.5\u00b138 months), 21 patients died; median survival of the group was 60 months (95% CI 43\u201377 months). Median survival for patients on pharmacotherapy additional to AS was 83 months (95% CI 57\u2013109 months), which was better than that for patients with AS alone (53 months, 95% CI 39\u201367 months) (log-rank 6.52; p=0.010).<\/jats:p><jats:p>In selected patients with PAH, AS is a safe and effective intervention that exerts a beneficial impact on long-term survival. Survival appears to be improved when AS is combined with PAH-specific pharmacotherapy.<\/jats:p>","DOI":"10.1183\/09031936.00072210","type":"journal-article","created":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T01:57:15Z","timestamp":1298599035000},"page":"1343-1348","source":"Crossref","is-referenced-by-count":125,"title":["Effect of atrial septostomy on the survival of patients with severe pulmonary arterial hypertension"],"prefix":"10.1183","volume":"38","author":[{"given":"J.","family":"Sandoval","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.E.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"C\u00f3rdova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"del Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Pulido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2011,2,24]]},"reference":[{"key":"2024102020350150000_38.6.1343.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.039"},{"key":"2024102020350150000_38.6.1343.2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"2024102020350150000_38.6.1343.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.4.1733"},{"key":"2024102020350150000_38.6.1343.4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0335"},{"key":"2024102020350150000_38.6.1343.5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.7.2028"},{"key":"2024102020350150000_38.6.1343.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70291-4"},{"key":"2024102020350150000_38.6.1343.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.02.019"},{"key":"2024102020350150000_38.6.1343.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00416-6"},{"key":"2024102020350150000_38.6.1343.9","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.9.797"},{"key":"2024102020350150000_38.6.1343.10","first-page":"164","article-title":"Graded balloon atrial septostomy in severe pulmonary hypertension","volume":"54","author":"Kothari","year":"2002","journal-title":"Indian Heart J"},{"key":"2024102020350150000_38.6.1343.11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0335"},{"key":"2024102020350150000_38.6.1343.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00238-1"},{"key":"2024102020350150000_38.6.1343.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.032"},{"key":"2024102020350150000_38.6.1343.14","unstructured":"Sandoval J Gaspar J . Atrial Septostomy. In: Peacock AJ Rubin LJ , eds. Pulmonary Circulation. 2nd Edn. London, Edward Arnold Publishers Ltd., 2004; pp. 319\u2013333."},{"key":"2024102020350150000_38.6.1343.15","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810240305"},{"key":"2024102020350150000_38.6.1343.16","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.077669"},{"key":"2024102020350150000_38.6.1343.17","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.11.1344"},{"key":"2024102020350150000_38.6.1343.18","first-page":"131","article-title":"Balloon atrial septostomy increases cardiac index and may reduce mortality among pulmonary hypertension patients awaiting lung transplantation","volume":"7","author":"Hayden","year":"1997","journal-title":"J Transpl Coord"},{"key":"2024102020350150000_38.6.1343.19","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.2.95"},{"key":"2024102020350150000_38.6.1343.20","doi-asserted-by":"crossref","unstructured":"Sandoval J Doyle R . Interventional and surgical modalities of treatment for pulmonary arterial hypertension. In: Barst R , ed. Pulmonary Arterial Hypertension: Diagnosis and Evidence-Based Treatment. Chichester, John Wiley & Sons Ltd., 2008; pp. 147\u2013179.","DOI":"10.1002\/9780470997390.ch8"},{"key":"2024102020350150000_38.6.1343.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00370-6"},{"key":"2024102020350150000_38.6.1343.22","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-006-1325-0"},{"key":"2024102020350150000_38.6.1343.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2006.02.002"},{"key":"2024102020350150000_38.6.1343.24","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20745"},{"key":"2024102020350150000_38.6.1343.25","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21216"},{"key":"2024102020350150000_38.6.1343.26","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1222"},{"key":"2024102020350150000_38.6.1343.27","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21760"},{"key":"2024102020350150000_38.6.1343.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.01.024"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00072210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:28:46Z","timestamp":1740378526000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00072210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,24]]},"references-count":28,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,11,30]]},"published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1183\/09031936.00072210"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00072210","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,24]]}}}