{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:10:15Z","timestamp":1793927415077,"version":"4.8.0"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,1,20]]},"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>Altitude illness remains a major cause of mortality. Reduced chemosensitivity, irregular breathing leading to central apnoeas\/hypopnoeas, and exaggerated pulmonary vasoconstriction may compromise oxygenation. All factors could enhance susceptibility to acute mountain sickness (AMS).<\/jats:p><jats:p>We compared 12 AMS-susceptible individuals with recurrent and severe symptoms (AMS+) with 12 \u201cAMS-nonsusceptible\u201d subjects (AMS-), assessing sleep-breathing disorders in simulated altitude as well as chemoresponsive and pulmonary vasoconstrictive responses to hypoxia.<\/jats:p><jats:p>During exposure to simulated altitude, mean blood oxygen saturation during sleep was lower in AMS+ subjects (81.6\u00b12.6<jats:italic>versus<\/jats:italic>86.0\u00b12.4%, p&lt;0.01), associated with a lower central apnoea\/hypopnoea index (18.2\u00b118.1<jats:italic>versus<\/jats:italic>33.4\u00b124.8 events\u00b7h<jats:sup>\u22121<\/jats:sup>in AMS+ and AMS- subjects, respectively; p=0.038). A lower hypoxic (isocapnic) chemoresponsiveness was observed in AMS+ subjects (0.40\u00b10.49<jats:italic>versus<\/jats:italic>0.97\u00b10.46 L\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7%; p&lt;0.001). This represented the only significant and independent predictive factor for altitude intolerance, despite a higher increase in pulmonary artery systolic pressure in response to hypoxia, a lower lung diffusing capacity and a higher endothelin-1 level at baseline in AMS+ subjects (p&lt;0.05). AMS+ subjects were more hypoxaemic whilst exhibiting fewer respiratory events during sleep owing to lower hypoxic (isocapnic) chemoresponsiveness.<\/jats:p><jats:p>In conclusion, the reduction in peripheral hypoxic chemosensitivity appears to be a major causative factor for altitude intolerance.<\/jats:p>","DOI":"10.1183\/09031936.00073111","type":"journal-article","created":{"date-parts":[[2012,4,21]],"date-time":"2012-04-21T03:04:14Z","timestamp":1334977454000},"page":"673-680","source":"Crossref","is-referenced-by-count":62,"title":["Altitude illness is related to low hypoxic chemoresponse and low oxygenation during sleep"],"prefix":"10.1183","volume":"40","author":[{"given":"Hugo","family":"Nespoulet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Wuyam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Tamisier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Saunier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Monneret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Remy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Chabre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"P\u00e9pin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"L\u00e9vy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2012,4,20]]},"reference":[{"key":"2024102021074360000_40.3.673.1","doi-asserted-by":"publisher","DOI":"10.1089\/15270290050144163"},{"key":"2024102021074360000_40.3.673.2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-8-199304150-00003"},{"key":"2024102021074360000_40.3.673.3","doi-asserted-by":"crossref","unstructured":"Basnyat B Murdoch DR . 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