{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:05:35Z","timestamp":1787958335717,"version":"build-2784847793"},"reference-count":32,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2007,12,17]]},"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>The aim of the present study was to assess associations between obstructive sleep apnoea and insulin sensitivity in a population-based sample of females.<\/jats:p><jats:p>In total, 400 females aged 20\u201370\u2005yrs underwent a full-night polysomnography, fasting blood sampling, measurement of anthropometric variables and oral glucose tolerance test with measurement of the insulin response (n\u200a=\u200a358). The apnoea\/hypopnoea index (AHI) was calculated from the results of the polysomnography. From the results of the oral glucose tolerance test, an insulin sensitivity index (ISI) was calculated.<\/jats:p><jats:p>Females with an AHI &lt;5 (n\u200a=\u200a119) had a mean\u00b1<jats:sc>sd<\/jats:sc>ISI of 8.3\u00b13.8, whereas females with an AHI \u226530 (n\u200a=\u200a34) had an ISI of 6.2\u00b14.0. Nocturnal minimal saturation was independently associated with decreased insulin sensitivity when controlling for age, waist\/hip ratio, level of physical activity, smoking and alcohol consumption (95% confidence interval (CI) 0.004\u20130.14). When adjusting for confounders, the AHI was associated with increased fasting and 2-h insulin levels (95% CI 0.14\u20130.99 and 95% CI 0.28\u20136.47, respectively).<\/jats:p><jats:p>Obstructive sleep apnoea was found to be independently associated with decreased insulin sensitivity in the present population-based sample of females.<\/jats:p>","DOI":"10.1183\/09031936.00074907","type":"journal-article","created":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T01:34:38Z","timestamp":1199928878000},"page":"1054-1060","source":"Crossref","is-referenced-by-count":61,"title":["Obstructive sleep apnoea is associated with decreased insulin sensitivity in females"],"prefix":"10.1183","volume":"31","author":[{"given":"J.","family":"Theorell-Hagl\u00f6w","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Berne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Janson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lindberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2008,1,9]]},"reference":[{"key":"2024102019290612000_31.5.1054.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"2024102019290612000_31.5.1054.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200302-206OC"},{"key":"2024102019290612000_31.5.1054.3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.4.447"},{"key":"2024102019290612000_31.5.1054.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2005.12.010"},{"key":"2024102019290612000_31.5.1054.5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00043306"},{"key":"2024102019290612000_31.5.1054.6","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.074351"},{"key":"2024102019290612000_31.5.1054.7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2000.00683.x"},{"key":"2024102019290612000_31.5.1054.8","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.5.387"},{"key":"2024102019290612000_31.5.1054.9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200407-906OC"},{"key":"2024102019290612000_31.5.1054.10","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/sleep\/28.5.601","volume":"28","year":"2005","journal-title":"Sleep"},{"key":"2024102019290612000_31.5.1054.11","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.5.2103001"},{"key":"2024102019290612000_31.5.1054.12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00089902"},{"key":"2024102019290612000_31.5.1054.13","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/sleep\/29.6.751","volume":"29","year":"2006","journal-title":"Sleep"},{"key":"2024102019290612000_31.5.1054.14","unstructured":"Rechtschaffen A, Kales A. eds. A Manual of Standardized Terminology, Techniques, and Scoring System for Sleep Stages in Human Subjects. Washington DC, US National Public Health Service, US Government Printing Office, 1968"},{"key":"2024102019290612000_31.5.1054.15","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/oxfordjournals.aje.a008657","volume":"143","year":"1996","journal-title":"Am J Epidemiol"},{"key":"2024102019290612000_31.5.1054.16","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.4.933"},{"key":"2024102019290612000_31.5.1054.17","unstructured":"Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Report of a WHO Consultation. Part 1: Diagnosis and Classification of Diabetes Mellitus. Geneva, World Health Organization, 1999; p.\u200559"},{"key":"2024102019290612000_31.5.1054.18","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"2024102019290612000_31.5.1054.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02407.x"},{"key":"2024102019290612000_31.5.1054.20","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.5.2104087"},{"key":"2024102019290612000_31.5.1054.21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2001.00787.x"},{"key":"2024102019290612000_31.5.1054.22","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200504-637OC"},{"key":"2024102019290612000_31.5.1054.23","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh261"},{"key":"2024102019290612000_31.5.1054.24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1003"},{"key":"2024102019290612000_31.5.1054.25","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01376-8"},{"key":"2024102019290612000_31.5.1054.26","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.7.2104126"},{"key":"2024102019290612000_31.5.1054.27","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.021022"},{"key":"2024102019290612000_31.5.1054.28","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.3.1151"},{"key":"2024102019290612000_31.5.1054.29","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/sleep\/29.3.329","volume":"29","year":"2006","journal-title":"Sleep"},{"key":"2024102019290612000_31.5.1054.30","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051591"},{"key":"2024102019290612000_31.5.1054.31","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1615"},{"key":"2024102019290612000_31.5.1054.32","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.4.8616563"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00074907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:08:10Z","timestamp":1740377290000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00074907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,9]]},"references-count":32,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,4,30]]},"published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1183\/09031936.00074907"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00074907","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,9]]}}}