{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:31:49Z","timestamp":1773430309956,"version":"3.50.1"},"reference-count":63,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,7,3]]},"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>Obstructive sleep apnoea (OSA) is common in children and leads to multiple end-organ morbidities. Myeloid-related protein (MRP) 8\/14 plays an important pathophysiological role in atherosclerosis, and plasma levels correlate with endothelial cell dysfunction. We hypothesised that MRP8\/14 levels would be altered in children with OSA.<\/jats:p><jats:p>255 children (aged 7.6\u00b11.5\u2005yrs) were included after a sleep study and a morning blood sample. MRP8\/14 and interleukin-6 plasma levels were assayed using ELISA and C-reactive protein by immunoturbidometry. Endothelial function was assessed as the hyperaemic response after occlusion of the brachial artery.<\/jats:p><jats:p>Plasma log MRP8\/14 levels showed apnoea\/hypopnoea index (AHI) dose-dependent increases regardless of obesity. Moreover, log MRP8\/14 levels correlated with log AHI (r\u200a=\u200a0.340, p&lt;0.001) after controlling for age and body mass index Z-score, and with endothelial function. Children with the highest MRP levels (&gt;1.34\u2005ug\u00b7mL<jats:sup>\u22121<\/jats:sup>) had 2.4- and 5.4-fold increased odds of mild OSA and moderate-to-severe OSA, respectively, after adjusting for confounding variables.<\/jats:p><jats:p>Plasma MRP8\/14 levels are associated with paediatric OSA and may reflect increased risk for cardiovascular morbidity. The short- and long-term consequences of elevated MRP8\/14 on cardiovascular function in the context of paediatric OSA remain to be defined.<\/jats:p>","DOI":"10.1183\/09031936.00075409","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T00:26:05Z","timestamp":1247790365000},"page":"843-850","source":"Crossref","is-referenced-by-count":54,"title":["Myeloid-related protein 8\/14 levels in children with obstructive sleep apnoea"],"prefix":"10.1183","volume":"35","author":[{"given":"J.","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. B.","family":"Snow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. 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